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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 182 - 185 (4page)
- DOI
- 10.13041/jpvm.2018.42.4.182
이용수
초록· 키워드
오류제보하기
This study examined the overdose toxicity of Super-Neophensan, containing florfenicol and acetaminophen, upon pigs. SNP-3.0 (n=10) was administered at the dosage level of 3 kg/ton feed for 7 consecutive days, which is 3 times the recommended dose based on the guidelines of the manufacturer, and the control group (CON) (n=10) was administered the normal diet without the drug. The body weight, weight gain and feed efficiency in SNP-3.0 treated with the drug for 14 days post-administration showed no significant differences compared with those in CON. In hematological and blood biochemical analyses, all parameters were not affected by over-dosage of the drug. In the same way, there were no significant differences between SNP-3.0 and CON on markers for liver and kidney functions. As no adverse effects were observed with the drug in an overdose oral toxicity test, this study suggests that the drug was identified as a safe agent in pigs administered with three times the recommended dose.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
차춘남 / 2017 / Effects of dietary acetaminophen and vitamin C supplement on serum cortisol and tumor necrosis factor-alpha concentrations in pigs vaccinated with foot-and-mouth disease vaccine / 대한수의학회지 57(3):197~200
Ferreira CS / 2007 / Acute toxicity of oxytetracycline and florfenicol to the microalgae Tetraselmis chuii and to the crustacean Artemia parthenogenetica / Ecotoxicol Environ Saf 67:452~458
James LP / 2003 / Acetaminophen-induced hepatotoxicity / Drug Metab Dispos 31:1499~1506
Lee KC / 2013 / A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival / Liver Int 33:544~551
Lucas R / 2005 / Cellular mechanisms of acetaminophen: role of cyclo-oxygenase / FASEB J 19:635~637
Ferreira CS / 2007 / Acute toxicity of oxytetracycline and florfenicol to the microalgae Tetraselmis chuii and to the crustacean Artemia parthenogenetica / Ecotoxicol Environ Saf 67:452~458
James LP / 2003 / Acetaminophen-induced hepatotoxicity / Drug Metab Dispos 31:1499~1506
Lee KC / 2013 / A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival / Liver Int 33:544~551
Lucas R / 2005 / Cellular mechanisms of acetaminophen: role of cyclo-oxygenase / FASEB J 19:635~637
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