지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 30 - 40 (11page)
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초록· 키워드
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Background: Acute kidney injury (AKI) is a risk factor for progression to chronic kidney disease, with even subclinical AKI episodes progressing to chronic kidney disease. Several risk factors such as preexisting kidney disease, hyperglycemia, and hypertension may aggravate renal disease after AKI. However, mechanisms underlying the progression of AKI are still unclear. This study identified the effect of human cluster of differentiation 36 (CD36) overexpression on the progression of folic acid-induced AKI. Methods: Pax8–rtTA/tetracycline response element–human CD36 transgenic mice were used to elucidate the effect of human CD36 overexpression in the proximal tubules on folic acid-induced AKI. Results: Results of histological analysis showed severely dilated tubules with casts and albuminuria in folic acid-treated transgenic mice overexpressing human CD36 compared with folic acid-treated wild-type mice. In addition, analysis of mRNA expression showed a significant increase in the collagen 3a1 gene in folic acid-treated transgenic mice overexpressing human CD 36 compared with folic acid-treated wild type mice. Conclusion: Human CD36-overexpressing transgenic mice showed severe pathological changes and albuminuria compared with wild-type mice. Moreover, mRNA expression of the collagen 3a1 gene increased in folic acid-treated transgenic mice. These results suggest that human CD36 overexpression is a risk factor of AKI and its progression to chronic kidney disease.
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참고문헌 (18)
참고문헌 신청
Uchino S / 2005 / Acute renal failure in critically ill patients: a multinational, multicenter study / JAMA 294:813~818
Lo LJ / 2009 / Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease / Kidney Int 76:893~899
Amdur RL / 2009 / Outcomes following diagnosis of acute renal failure in U.S. veterans: focus on acute tubular necrosis / Kidney Int 76:1089~1097
Ishani A / 2009 / Acute kidney injury increases risk of ESRD among elderly / J Am Soc Nephrol 20:223~228
Chawla LS / 2011 / Acute kidney injury leading to chronic kidney disease and long-term outcomes of acute kidney injury: the best opportunity to mitigate acute kidney injury? / Contrib Nephrol 174:182~190
Lo LJ / 2009 / Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease / Kidney Int 76:893~899
Amdur RL / 2009 / Outcomes following diagnosis of acute renal failure in U.S. veterans: focus on acute tubular necrosis / Kidney Int 76:1089~1097
Ishani A / 2009 / Acute kidney injury increases risk of ESRD among elderly / J Am Soc Nephrol 20:223~228
Chawla LS / 2011 / Acute kidney injury leading to chronic kidney disease and long-term outcomes of acute kidney injury: the best opportunity to mitigate acute kidney injury? / Contrib Nephrol 174:182~190
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