The Protective Effect of Maternal Folic Acid Supplementation on Childhood Cancer: A Systematic Review and Meta-analysis of Case-control Studies

Wan Rosmawati Wan Ismail; Raudah Abdul Rahman; Nur Ashiqin Abd Rahman; Azman Atil; Azmawati Mohammed Nawi

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자료유형: 학술저널

저자정보: Wan Rosmawati Wan Ismail Raudah Abdul Rahman Nur Ashiqin Abd Rahman Azman Atil Azmawati Mohammed Nawi

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제52권 제4호

발행연도: 2019.1

수록면: 205 - 213 (9page)

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Objectives: Maternal folic acid supplementation is considered mandatory in almost every country in the world to prevent congenital malformations. However, little is known about the association of maternal folic acid intake with the occurrence of childhood cancer. Hence, this study aimed to determine the effects of maternal folic acid consumption on the risk of childhood cancer. Methods: A total of 158 related articles were obtained from PubMed, Google Scholar, Scopus, and ProQuest using standardized keywords, of which 17 were included in the final review. Results: Eleven of the 17 articles showed a significant protective association between maternal folic acid supplementation and childhood cancer. Using a random-effects model, pooled odds ratios (ORs) showed a protective association between maternal folic acid supplementation and childhood acute lymphoblastic leukaemia (OR, 0.75; 95% confidence interval [CI], 0.66 to 0.86). However, there was no significant association between maternal folic acid supplementation and acute myeloid leukaemia (OR, 0.70; 95% CI, 0.46 to 1.06) or childhood brain tumours (OR, 1.02; 95% CI, 0.88 to 1.19). Conclusions: Maternal folic acid supplementation was found to have a protective effect against childhood acute lymphoblastic leukaemia. Thus, healthcare professionals are recommended to provide regular health education and health promotion to the community on the benefits of folic acid supplementation during pregnancy.

참고문헌 (53)

참고문헌 신청

Steliarova-Foucher E / 2017 / International incidence of childhood cancer, 2001-10 : a population-based registry study / Lancet Oncol 18(6):719~731

Gupta S / 2015 / Cancer: disease control priorities / World Bank

Howard SC / 2018 / The My Child Matters programme : effect of public–private partnerships on paediatric cancer care in low-income and middle-income countries / Lancet Oncol 19(5):e252~e266

Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68(6):394~424

Linet MS / 2003 / Interpreting epidemiologic research: lessons from studies of childhood cancer / Pediatrics 112(1 Pt 2):218~232

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