지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1 - 6 (6page)
이용수
초록· 키워드
오류제보하기
OBJECTIVES: Numerous studies have demonstrated that fasting serum glucose (FSG) levels and certain single-nucleotide polymorphisms (SNPs) are related to an increased risk of colorectal cancer (CRC); however, their combined effects are still unclear. METHODS: Of a total of 144,527 men and women free of cancer at baseline, 317 developed CRC during 5.3 years of follow-up. A case-cohort study (n=1,691) was used, consisting of participants with a DNA sample available. Three well-known SNPs (rs3802842, rs6983267, rs10795668) were genotyped. Hazard ratios (HR) and 95% confidence intervals (CI) of CRC, colon and rectal cancer were calculated, with the Cox proportional hazard models. RESULTS: The crude incidence rates per 100,000 person-years were 41.1 overall, 48.4 for men, and 29.3 for women. Among participants with dysglycemia, SNPs rs3802842 and rs6983267 were both associated with an increased risk of CRC (HR, 3.2; 95% CI, 1.9 to 5.5 and HR, 1.8; 95% CI, 1.1 to 3.1, respectively) and rectal cancer (HR, 3.4; 95% CI, 1.8 to 6.6 and HR, 3.3; 95% CI, 1.6 to 7.1, respectively). The interaction effect of dysglycemia and SNPs was positive, that is, resulted in an elevated risk of CRC, but was not statistically significant. CONCLUSIONS: This study demonstrates that both high FSG and certain SNPs are major risk factors for CRC and rectal cancer but that they did not interact synergistically. The difference in effect size of the SNPs according to CRC subtype (i.e., colon or rectal cancer) and presence of dysglycemia merits further research.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Geographic distribution of the incidence of colorectal cancer in Iran: a population-based study
Epidemiology and Health
2017 .01
-
Application of a non-parametric non-mixture cure rate model for analyzing the survival of patients with colorectal cancer in Iran
Epidemiology and Health
2018 .01
-
Association of the inflammatory balance of diet and lifestyle with colorectal cancer among Korean adults: a case–control study
Epidemiology and Health
2022 .01
-
High-quality SNP calling from olive flounder, Paralichthys olivaceus, in Jeju Island, South Korea
한국수산과학회 양식분과 학술대회
2021 .04
-
High Level of Sequence-Variation in Sacbrood Virus (SBV) from Apis mellifera
Journal of Apiculture
2017 .11
-
Identification of functional SNPs in genes and their effects on plant phenotypes
Journal of Plant Biotechnology
2016 .01
-
Single Nucleotide Polymorphism of TBC1D1 Gene Association with Growth Traits and Serum Clinical-Chemical Traits in Chicken
한국가금학회지
2018 .12
-
유전자 단위 haplotype을 대변하는 토마토 Tag-SNP 선발 및 웹 데이터베이스 구축
Journal of Plant Biotechnology
2020 .01
-
Genetic Variability and Genome-wide Association Study in Pumpkins (Cucurbita moschata)
한국원예학회 학술발표요지
2021 .05
-
Association Mapping and Development of SNP Marker Using GBS-Based SNPs in Apples
한국원예학회 학술발표요지
2018 .10
-
한우 유전자칩(Hanwoo 50K chip)을 이용한 전라북도 한우의 연관불평형 분석
Journal of Animal Breeding and Genomics
2022 .12
-
The medium-term consequences of COVID-19 lockdown on lifestyle among Spanish older people with hypertension, pulmonary, cardiovascular, and musculoskeletal-diseases, depression, and cancer
Epidemiology and Health
2022 .01
-
An update of physical genomic information for commercial bovine SNP chip based on the ARS-UCD1.2 reference genome
Journal of Animal Breeding and Genomics
2021 .12
-
한국 재래계의 HNF4α 유전자 내 SNP와 성장과의 연관성 분석
한국가금학회지
2018 .12
-
Development of Genome-wide Single Nucleotide Polymorphisms(SNPs) in the Korean Chrysanthemum Germplasm Collection
한국원예학회 학술발표요지
2021 .10
-
Risk factors for stomach cancer: a systematic review and meta-analysis
Epidemiology and Health
2020 .01
-
SNP마커 개발을 통한 사료용 옥수수 품종판별
한국초지조사료학회지
2017 .01
-
Identification of Genome-wide SNPs by Genotyping by Sequencing in a Collection of Pear cultivars
한국원예학회 학술발표요지
2021 .10
-
Development of High-throughput Marker Set for Seed Quality Screening in Cucurbita moschata
한국원예학회 학술발표요지
2021 .10
-
Genome-wide SNP Identification in Two Hot Pepper Cultivars with Contrasting Bacterial Wilt Resistance Traits
한국원예학회 학술발표요지
2021 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0