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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국낙농식품응용생물학회 Journal of Dairy Science and Biotechnology Journal of Milk Science and Biotechnology Vol.36 No.1
- 발행연도
- 2018.1
- 수록면
- 39 - 48 (10page)
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초록· 키워드
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This study examined the immunomodulatory effects of milk fermented with based on the synbiotic interaction between Cudrania tricuspidata leaf extract (CT) and Lactobacillus gasseri 505. Raw 264.7 macrophages were treated with milk (Control), milk supplemented with 0.2% CT (CT-milk), or CT-milk fermented with L. gasseri 505 (FCT). FCT-treated cells showed higher NO production than the other groups. ELISA revealed that FCT produced the highest enhancement of the production of pro-inflammatory cytokines such as TNF-α, IFN-γ, IL-1β, IL-6, IL-2, IL-12, and IL-10. Furthermore, FCT also increased the gene expression of pro-inflammatory mediators such as iNOS and COX-2 in a concentration-dependent manner. Collectively, these results indicate that the synbiotic interaction between CT and L. gasseri 505 might enhance their immunomodulatory effects of fermented milk.
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참고문헌 (28)
참고문헌 신청
Arakawa, K. / 2008 / Bacteriocin production of probiotic Lactobacillus gasseri LA39 isolated from human feces in milk-based media / Animal Science Journal 79(5):634~640
Ashraf, R. / 2014 / Lactic acid bacteria and probiotic organisms induce different cytokine profile and regulatory T cells mechanisms / Journal of Functional Foods 6:395~409
Bermudez-Brito, M. / 2014 / Lactobacillus rhamnosus and its cell-free culture supernatant differentially modulate inflammatory biomarkers in Escherichia coli-challenged human dendritic cells / British Journal of Nutrition 111(10):1727~1737
Chiba, Y. / 2010 / Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei / Immunology 130(3):352~362
Delgado, A. V. / 2003 / Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P / Neuropeptides 37(6):355~361
Ashraf, R. / 2014 / Lactic acid bacteria and probiotic organisms induce different cytokine profile and regulatory T cells mechanisms / Journal of Functional Foods 6:395~409
Bermudez-Brito, M. / 2014 / Lactobacillus rhamnosus and its cell-free culture supernatant differentially modulate inflammatory biomarkers in Escherichia coli-challenged human dendritic cells / British Journal of Nutrition 111(10):1727~1737
Chiba, Y. / 2010 / Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei / Immunology 130(3):352~362
Delgado, A. V. / 2003 / Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P / Neuropeptides 37(6):355~361
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