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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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This study was conducted to investigate the effect of chronic alcohol supplementation on muscle atrophy in growing rats. Eighteen male Sprague Dawley rats were randomly divided into two groups: CG group (control group, n=9) and AG group (alcohol supplemented group, n=9). Alcohol group (3 g/kg BW) was orally supplemented every day. After the experimental period, serum components and muscle Akt, p-Akt, FoxO, p-FoxO, MuRF1, and P38 protein expressions were analyzed. In the results, the values of EDL and soleus muscle weights of AG group did not have significant differences compared to the value of the CG group. In the serum components, the value of the serum TG concentration of AG group was significantly increased compared to the value of the CG group. The value of the p-Akt/Akt and p-FoxO/FoxO of the AG group was significantly decreased compared to the value of the CG group (p<0.01). The MuRF1 protein expression of AG group was significantly increased compared to the value of the CG group (p<0.01). However, the values of p-P38/P38 between two groups did not have any significant difference. From these results, it was suggested that 4 weeks of chronic alcohol supplementation induced muscle atrophy via activated protein degradation pathway involving the inhibition of Akt phosphorylation and increased FoxO and MuRF1 protein expression of muscle in growing rats.
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참고문헌 (30)
참고문헌 신청
Ministry of education / 2015 / Online survey of youth health behavior. No. 117058
Blaauw B / 2010 / Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation / Biophysical. J 98:153a
Bodine SC / 2001 / Identification of ubiquitin ligases required for skeletal muscle atrophy / Science 294:1704~1708
Brown SA / 2000 / Neurocognitive functioning of adolescents: effects of protracted alcohol use / Alcohol Clin. Exp. Res 24:164~171
Clary CR / 2011 / Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats / AIDS Res. Ther 8:30
Blaauw B / 2010 / Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation / Biophysical. J 98:153a
Bodine SC / 2001 / Identification of ubiquitin ligases required for skeletal muscle atrophy / Science 294:1704~1708
Brown SA / 2000 / Neurocognitive functioning of adolescents: effects of protracted alcohol use / Alcohol Clin. Exp. Res 24:164~171
Clary CR / 2011 / Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats / AIDS Res. Ther 8:30
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