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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The aim was to evaluate the diagnostic utility of beta-amyloid positron emission tomography (PET) in elderly patients with cognitive impairment in the clinical setting. Five subjects underwent beta-amyloid PET imaging to explore the cerebral beta-amyloid deposition. The two male patients with minor neurocognitive disorder due to Alzheimer’s disease, who displayed similar degree of cognitive impairment and medial temporal atrophy but different in apolipoprotein E4 status, both showed negative for beta-amyloid PET. On the other hand, a female major neurocognitive disorder due to probable Alzheimer’s disease patient was tested positive for beta-amyloid PET, with increased beta-amyloid density in frontal and parietal lobes. Beta-amyloid PET was also used for the differential diagnosis of neurocognitive disorder from other psychiatric disorders in two elderly patients. The results were negative but assisted the diagnositic confirmation. A female patient was determined to be a case of late-onset schizophrenia and a male patient was determined as delirium due to minor traumatic brain injury, persistent. Beta-amyloid PET imaging was able to demonstrate cerebral beta-amyloid deposition in major neurocognitive disorder due to probable Alzheimer’s disease in visual scale. However, further studies are needed for its clinical utility in the minor neurocognitive disorders. Moreover, beta-amyloid PET imaging may provide additional information in diagnosing primary psychiatric disorders with new onset in the old age.
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참고문헌 (37)
참고문헌 신청
Ministry of Health and Welfare / 2012 survey of dementia prevalence
Ott A / 1995 / Prevalence of Alzheimer’s disease and vascular dementia: association with education. The Rotterdam study / BMJ 310:970~973
Taipa R / 2012 / Clinico-pathological correlations of the most common neurodegenerative dementias / Front Neurol 3:68
Hurt C / 2008 / Patient and caregiver perspectives of quality of life in dementia. An investigation of the relationship to behavioural and psychological symptoms in dementia / Dement Geriatr Cogn Disord 26:138~146
Berg L / 1988 / Mild senile dementia of the Alzheimer type: 2. Longitudinal assessment / Ann Neurol 23:477~484
Ott A / 1995 / Prevalence of Alzheimer’s disease and vascular dementia: association with education. The Rotterdam study / BMJ 310:970~973
Taipa R / 2012 / Clinico-pathological correlations of the most common neurodegenerative dementias / Front Neurol 3:68
Hurt C / 2008 / Patient and caregiver perspectives of quality of life in dementia. An investigation of the relationship to behavioural and psychological symptoms in dementia / Dement Geriatr Cogn Disord 26:138~146
Berg L / 1988 / Mild senile dementia of the Alzheimer type: 2. Longitudinal assessment / Ann Neurol 23:477~484
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