지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.1
- 발행연도
- 2018.1
- 수록면
- 138 - 146 (9page)
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초록· 키워드
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Background/Aims Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) prevents chronic stress-mediated brain function abnormalities by attenuating the HPA axis response. Here, we compared the effect between different probiotic treatments on the perception of visceral pain during colorectal distension (CRD) following a chronic stress and the consequences to the activity of the HPA axis. Methods After a 2-week treatment with a combined probiotic formulation, or L. helveticus or B. longum alone in stressed mice, the visceral pain in response to CRD was recorded. The expression of glucocorticoid receptors was determined in the different brain areas involved in the stress response (hypothalamus, hippocampus, and prefrontal cortex). The plasma levels of stress hormones were also measured. Results A pretreatment using the combination of probiotic formulation significantly reduces the chronic stress-induced visceral hypersensitivity respectively at 0.06, 0.08, and 0.10 mL CRD volume. However, a single probiotic (B. longum or L. helveticus) administration is less effective in reducing visceral pain in stressed mice. Moreover, the expression of the glucocorticoid receptor mRNA was consistently up-regulated in several brain areas after pretreatment with a combined probiotic, which correlated with the normalization of stress response compared to the inconsistent effects of a single probiotic. Conclusion The combination of L. helveticus and B. longum is more effective in regulating glucocorticoid negative feedback on the HPA axis than probiotic alone and subsequently in treating stress-induced visceral pain.
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등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Canavan C / 2014 / The epidemiology of irritable bowel syndrome / Clinical Epidemiol 6:71~80
Chey WD / 2015 / Irritable bowel syndrome: a clinical review / JAMA 313:949~958
Whitehead WE / 1992 / Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction / Gut 33:825~830
Moloney RD / 2015 / Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities / Frontiers Psychiatry 6:15
Thijssen AY / 2010 / Dysfunctional cognitions, anxiety and depression in irritable bowel syndrome / J Clin Gastroenterol 44:e236~e241
Chey WD / 2015 / Irritable bowel syndrome: a clinical review / JAMA 313:949~958
Whitehead WE / 1992 / Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction / Gut 33:825~830
Moloney RD / 2015 / Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities / Frontiers Psychiatry 6:15
Thijssen AY / 2010 / Dysfunctional cognitions, anxiety and depression in irritable bowel syndrome / J Clin Gastroenterol 44:e236~e241
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