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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: The aim of this study was to investigate the effect of N-methyl-N-nitrosourea (MNU) treatment followed by chronic Helicobacter pylori SS1 and H. felis colonization on the stomachs of C57BL/6 mice. The role of MNU and Helicobacter species in gastric carcinogenesis was also elucidated. Methods: A total of 69 C57BL/6 mice at 4 weeks of age were divided into 6 groups according to MNU treatment and H. pylori SS1 or H. felis infection. The mice were sacrificed at 21 and 50 weeks. The degree of inflammation was determined by histopathology. The levels of gastric mucosal myeloperoxidase, TNF-α, and interleukin-1β (IL-1β) were measured by ELISA. Results: In the H. felis groups with or without MNU, the incidence of gastric tumors was 21.1% and 35.0% at 21 and 50 weeks, respectively. No gastric tumors were observed in all control mice. At 50 weeks, 37.5% of gastric adenoma cases were observed in the H. felis alone and MNU + H. felis groups. Furthermore, 12.5% of gastric adenocarcinoma cases were observed in the MNU alone and MNU + H. felis groups. The gastric mucosal IL-1 level was significantly higher in the MNU + H. felis group at 21 weeks and H. felis group at 50 weeks, respectively, than that for control mice (P ＜ 0.05). However, the effect of MNU on H. pylori SS1-induced gastric carcinogenesis was low compared to that on H. felis. Conclusions: Administration of MNU before H. felis infection provokes severe inflammation through IL-1β, and eventually induces gastric cancer. However, the role of MNU in H. pylori SS1-induced gastric carcinogenesis model is minor.
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참고문헌 (16)
참고문헌 신청
Ju Yup Lee / 2014 / No Correlation of Inflammation With Colonization of Helicobacter pylori in the Stomach of Mice Fed High-salt Diet / 대한암예방학회지 19(2):144~151
이주엽 / 2016 / Anti-inflammatory and Anti-tumorigenic Effects of Açai Berry in Helicobacter felis-infected mice / 대한암예방학회지 21(1):48~54
Tatematsu M / 1992 / Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea / Jpn J Cancer Res 83:915~918
Li Q / 2012 / Disruption of Klf4in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice / Gastroenterology 142:531~542
Tsukamoto T / 2007 / Animal models of stomach carcinogenesis / Toxicol Pathol 35:636~648
이주엽 / 2016 / Anti-inflammatory and Anti-tumorigenic Effects of Açai Berry in Helicobacter felis-infected mice / 대한암예방학회지 21(1):48~54
Tatematsu M / 1992 / Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea / Jpn J Cancer Res 83:915~918
Li Q / 2012 / Disruption of Klf4in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice / Gastroenterology 142:531~542
Tsukamoto T / 2007 / Animal models of stomach carcinogenesis / Toxicol Pathol 35:636~648
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