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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 62 - 68 (7page)
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초록· 키워드
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Background/Aims: The use of anti-tumor necrosis factor (anti-TNF) agents seems to reduce surgical rates and delay surgicalprocedures in prospective trials and population-based studies in the management of Crohn’s disease (CD). This study aimedto identify whether preoperative anti-TNF agents influence the time from diagnosis to surgery. Methods: An observationalretrospective cohort study was conducted on patients with CD submitted to intestinal resections due to complications ormedical therapy failure in a period of 7 years. The patients were allocated into 2 groups according to their previous exposure toanti-TNF agents in the preoperative period. Epidemiological aspects regarding age at diagnosis, smoking, perianal disease, andpreoperative conventional therapy were considered. A Kaplan-Meier survival analysis was used to outline possible differencesbetween the groups regarding the time to surgery. Results: A total of 123 patients were included (71 and 52 with and withoutprevious exposure to biologics, respectively). The overall time to surgery was 108±6.9 months (maximum, 276 months). The survival estimation revealed no difference in the mean time to intestinal resection between the groups (99.78±10.62 months inthe patients without and 114.01±9.07 months in those with previous anti-TNF use) (log-rank P =0.35). There was no significantdifference in the time to surgery regarding perianal CD (P =0.49), smoking (P =0.63), preoperative azathioprine (P =0.073) andsteroid use (P =0.58). Conclusions: The time from diagnosis to surgery was not influenced by the preoperative use of anti-TNFtherapy in this cohort of patients.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Khanna R / 2015 / Early combined immunosuppression for the management of Crohn's disease (REACT): a cluster randomised controlled trial / Lancet 386:1825~1834
Pariente B / 2011 / Development of the Crohn's disease digestive damage score, the Lemann score / Inflamm Bowel Dis 17:1415~1422
Kotze PG / 2017 / Tumor necrosis factor alpha inhibitors did not influence postoperative morbidity after elective surgical resections in Crohn's disease / Dig Dis Sci 62:456~464
Ramadas AV / 2010 / Natural history of Crohn's disease in a population-based cohort from Cardiff (1986-2003): a study of changes in medical treatment and surgical resection rates / Gut 59:1200~1206
Rungoe C / 2014 / Changes in medical treatment and surgery rates in inflammatory bowel disease: a nationwide cohort study 1979-2011 / Gut 63:1607~1616
Pariente B / 2011 / Development of the Crohn's disease digestive damage score, the Lemann score / Inflamm Bowel Dis 17:1415~1422
Kotze PG / 2017 / Tumor necrosis factor alpha inhibitors did not influence postoperative morbidity after elective surgical resections in Crohn's disease / Dig Dis Sci 62:456~464
Ramadas AV / 2010 / Natural history of Crohn's disease in a population-based cohort from Cardiff (1986-2003): a study of changes in medical treatment and surgical resection rates / Gut 59:1200~1206
Rungoe C / 2014 / Changes in medical treatment and surgery rates in inflammatory bowel disease: a nationwide cohort study 1979-2011 / Gut 63:1607~1616
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