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학술저널
저자정보
Way-Seah Lee (University of Malaya Faculty of Medicine) Najib Azmi (University of Malaya Faculty of Medicine) Ruey-Terng Ng (University of Malaya Faculty of Medicine) Sik-Yong Ong (University of Malaya Faculty of Medicine) Sasheela Sri La Ponnampalavanar (University of Malaya Faculty of Medicine) Sanjiv Mahadeva (University of Malaya Faculty of Medicine) Ida Hilmi (University of Malaya Faculty of Medicine)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.15 No.4
발행연도
2017.1
수록면
524 - 528 (5page)

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Anti-tumor necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD); however, it is associated with an increased risk of infections, particularly in older adults. We reviewed 349 patients with IBD, who were observed over a 12-month period, 74 of whom had received anti-TNF therapy (71 patients were aged <60 years and 3 were aged ≥60 years). All the 3 older patients developed serious infectious complications after receiving anti-TNFs, although all of them were also on concomitant immunosuppressive therapy. One patient developed disseminated tuberculosis, another patient developed cholera diarrhea followed by nosocomial pneumonia, while the third patient developed multiple opportunistic infections (Pneumocystis pneumonia, cryptococcal septicemia and meningitis, Klebsiella septicemia). All 3 patients died within 1 year from the onset of the infection(s). We recommend that anti-TNF, especially when combined with other immunosuppressive therapy, should be used with extreme caution in older adult patients with IBD.

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