Fatal infections in older patients with inflammatory bowel disease on anti-tumor necrosis factor therapy

Way-Seah Lee; Najib Azmi; Ruey-Terng Ng; Sik-Yong Ong; Sasheela Sri La Ponnampalavanar; Sanjiv Mahadeva; Ida Hilmi

추천

검색

자료유형: 학술저널

저자정보: Way-Seah Lee (University of Malaya Faculty of Medicine) Najib Azmi (University of Malaya Faculty of Medicine) Ruey-Terng Ng (University of Malaya Faculty of Medicine) Sik-Yong Ong (University of Malaya Faculty of Medicine) Sasheela Sri La Ponnampalavanar (University of Malaya Faculty of Medicine) Sanjiv Mahadeva (University of Malaya Faculty of Medicine) Ida Hilmi (University of Malaya Faculty of Medicine)

저널정보: 대한장연구학회 Intestinal research Intestinal research Vol.15 No.4

발행연도: 2017.1

수록면: 524 - 528 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Anti-tumor necrosis factor (anti-TNF) is highly effective in inflammatory bowel disease (IBD); however, it is associated with an increased risk of infections, particularly in older adults. We reviewed 349 patients with IBD, who were observed over a 12-month period, 74 of whom had received anti-TNF therapy (71 patients were aged <60 years and 3 were aged ≥60 years). All the 3 older patients developed serious infectious complications after receiving anti-TNFs, although all of them were also on concomitant immunosuppressive therapy. One patient developed disseminated tuberculosis, another patient developed cholera diarrhea followed by nosocomial pneumonia, while the third patient developed multiple opportunistic infections (Pneumocystis pneumonia, cryptococcal septicemia and meningitis, Klebsiella septicemia). All 3 patients died within 1 year from the onset of the infection(s). We recommend that anti-TNF, especially when combined with other immunosuppressive therapy, should be used with extreme caution in older adult patients with IBD.

참고문헌 (16)

참고문헌 신청

Dignass A / 2010 / The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: current management / J Crohns Colitis 4:28~62

Dignass A / 2012 / Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management / J Crohns Colitis 6:991~1030

Hanauer SB / 2002 / Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial / Lancet 359:1541~1549

Sandborn WJ / 2007 / Adalimumab for maintenance treatment of Crohn’s disease: results of the CLASSIC II trial / Gut 56:1232~1239

Schreiber S / 2007 / Maintenance therapy with certolizumab pegol for Crohn’s disease / N Engl J Med 357:239~250

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!