지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Overactive bladder (OAB) is a symptom-driven condition characterized by urinary urgency with or without urinary incontinence and a common problem that can significantly affect quality of life. Drugs that prevent acetylcholinemediated involuntary detrusor contractions are the mainstay of OAB treatment, but several alternative therapeutic options have become established treatments for OAB. Mirabegron (a β3-adrenoceptor agonist) has a different mechanism of action from antimuscarinic agents. Recently published randomized controlled trials have shown that mirabegron is an effective and safe drug for the symptomatic treatment of OAB patients. Mirabegron represents a valid option both for patients with OAB who are antimuscarinics treatment-naïve, as well as for those who are unresponsive or intolerant to antimuscarinics. Intravesical injection of botulinum toxin A is an effective treatment for OAB that is refractory to antimuscarinics. Treatment with botulinum toxin A showed clinically relevant improvement in all OAB symptoms and health-related quality of life. It was generally well tolerated by most patients, and most treatment-related complications were acceptable. However, increased risk of a larger volume of post-void residual urine was noted in several patients and the possibility of chronic catheterization requires careful evaluation before treatment. In sum, recent options for management of OAB, mirabegron and intravesical injection of botulinum toxin A, expand the treatment options for the optimal treatment of each patient.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Abrams P / 2002 / The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society / Neurourol Urodyn 21:167~178
Irwin DE / 2006 / Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study / Eur Urol 50:1306~1314
Lee YS / 2011 / Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms: results of Korean EPIC study / World J Urol 29:185~190
Sexton CC / 2011 / Prevalence and effect on health-related quality of life of overactive bladder in older Americans: results from the epidemiology of lower urinary tract symptoms study / J Am Geriatr Soc 59:1465~1470
Gormley EA / 2012 / Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline / J Urol 188(6):2455~2463
Irwin DE / 2006 / Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study / Eur Urol 50:1306~1314
Lee YS / 2011 / Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms: results of Korean EPIC study / World J Urol 29:185~190
Sexton CC / 2011 / Prevalence and effect on health-related quality of life of overactive bladder in older Americans: results from the epidemiology of lower urinary tract symptoms study / J Am Geriatr Soc 59:1465~1470
Gormley EA / 2012 / Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline / J Urol 188(6):2455~2463
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