지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 507 - 513 (7page)
이용수
초록· 키워드
오류제보하기
Objective To find out the factors affecting medication discontinuation in patients with overactive bladder (OAB) symptoms.
Methods The clinical data of 125 patients with OAB symptoms who had taken antimuscarinics and behavioral therapy were retrospectivelyreviewed. Antimuscarinics related outcomes were evaluated by an independent observer with telephone interview. All patients were asked about duration of medication and reason of continuation or discontinuation of antimuscarinics.
To determine pre-treatment factors predicting self-report discontinuation of antimuscarinics, variables of only those with P-values <0.25 on the univariate analysis were included in the Cox proportional hazard modeling.
Results Mean follow-up was 39.6 months and the proportion of discontinuation of antimuscarinics was 60.0% (75/125). The mean duration of medication was 21.2 months in the continuation group and 3.3 months in the discontinuationgroup. The reasons of discontinuation of antimuscarinics were improved OAB symptoms (46.7%), tolerable OAB symptoms (33.3%), no change of OAB symptoms (1.3%), side-effects (8.0%) and no desire to take long-term medication(10.7%). The variables affecting remaining cumulative probability of antimuscarinics were age, history of anti-incontinence surgery or vaginal surgery, and having stress predominant urinary incontinence on urodynamic study.
Conclusion The lower rate of cumulative continuation of antimuscarinics encourages us to give a more detailed counseling and education to the patients with OAB symptoms before prescription. And explorations about newer agent and non-pharmacologic treatment with good efficacy and lower side-effects are needed.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abrams P. / 2002 / The standardisation of terminology of lower urinary tract function : report from the Standardisation Sub-committee of the International Continence Society
Balkrishnan R. / 2006 / Predictors of medication adherence and associated health care costs in an older population with overactive bladder syndrome: a longitudinal cohort st
Basra RK. / 2008 / A review of adherence to drug therapy in patients with overactive bladder / BJU Int 102 : 774 ~ 779
Benner JS. / 2010 / Patient-reported reasons for discontinuing overactive bladder medication / BJU Int 105 : 1276 ~ 1282
Brubaker L. / 2010 / Predictors of discontinuing overactive bladder medications / BJU Int 105 : 1283 ~ 1290
Balkrishnan R. / 2006 / Predictors of medication adherence and associated health care costs in an older population with overactive bladder syndrome: a longitudinal cohort st
Basra RK. / 2008 / A review of adherence to drug therapy in patients with overactive bladder / BJU Int 102 : 774 ~ 779
Benner JS. / 2010 / Patient-reported reasons for discontinuing overactive bladder medication / BJU Int 105 : 1276 ~ 1282
Brubaker L. / 2010 / Predictors of discontinuing overactive bladder medications / BJU Int 105 : 1283 ~ 1290
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