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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 235 - 241 (7page)
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초록· 키워드
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Cartilage repair is substantially intractable due to poor self-healing ability. Porous microspheres can be a fascinating three-dimensional matrix for cell culture and injectable carrier in cartilage engineering. In this study, we assessed the feasible use of porous biopolymer microspheres for chondrocyte carriers. When seeded onto the blended biopolymer microspheres and followed by a dynamic spinner flask culture, the chondrocytes showed robust growth behaviors during the culture period. The gene expressions of SOX9, type II collagen, and aggrecan were significantly upregulated after 2-week of culture. Furthermore, immunolocalization of type II collagen and secretion of glycosaminolglycan became prominent. The results suggest the feasible usefulness of the porous microspheres as the cell culture matrix and the subsequent delivery into cartilage defects.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Hunziker EB / 2002 / Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects / Osteoarthritis Cartilage 10:432~463
Langer R / 1993 / Tissue engineering / Science 260:920~926
Vinatier C / 2009 / Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy / Curr Stem Cell Res Ther 4:318~329
Ruuskanen MM / 1994 / Generation of cartilage from auricular and rib free perichondrial grafts around a self-reinforced polyglycolic acid mould in rabbits / Scand J Plast Reconstr Surg Hand Surg 28:81~86
Chen J / 2005 / In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells / Cell Tissue Res 319:429~438
Langer R / 1993 / Tissue engineering / Science 260:920~926
Vinatier C / 2009 / Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy / Curr Stem Cell Res Ther 4:318~329
Ruuskanen MM / 1994 / Generation of cartilage from auricular and rib free perichondrial grafts around a self-reinforced polyglycolic acid mould in rabbits / Scand J Plast Reconstr Surg Hand Surg 28:81~86
Chen J / 2005 / In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells / Cell Tissue Res 319:429~438
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