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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 261 - 269 (9page)
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Recent research suggests that a small group of cells, named cancer stem cells (CSCs), is responsible for initiating tumor formation, recurrence, and metastasis. c-Yes, a proto-oncogene that is a subfamily of Src family kinase, is often activated in human colon cancer; this implicates c-Yes in the onset and progression of the disease. The objective of this study was to investigate the correlation between c-Yes and CSCs. We performed a sphere formation assay and reverse transcription-polymerase chain reaction for studying the differentiation of HT-29 human colon CSCs. To demonstrate the specific role of c-Yes in CSCs, we performed live cell microscopy and a cell cycle assay. These study shows, for the first time, that c-Yes is enriched in CD133+ CSCs, compared to their CD133− counterparts, and that c-Yes depletion in CD133+ cells induces cell differentiation. Moreover, c-Yes depletion was found to elongate the midbody and increase the proliferation doubling time. This also suggested that the misregulation of microtubules during chromosomal separation causes aneuploidy. Our results suggest that c-Yes may play a crucial role in initiating, maintaining, and driving the tumorigenic property of colon cancer.
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참고문헌 (26)
참고문헌 신청
Pohl A / 2008 / Stem cells in colon cancer / Clin Colorectal Cancer 7:92~98
LaBarge MA / 2008 / Is CD133 a marker of metastatic colon cancer stem cells? / J Clin Invest 118:2021~2024
Fabrizi E / 2010 / Therapeutic implications of colon cancer stem cells / World J Gastroenterol 16:3871~3877
Puglisi M / 2008 / Identification of CD133-cancer stem cells in hepatic metastasis from colon cancer / Gastroenterology 134:A447~A448
Varnat F / 2009 / CD133+cancer stem cells are more prevalent in metastatic than non-metastatic colon carcinomas / Swiss Med Wkly 139:6S
LaBarge MA / 2008 / Is CD133 a marker of metastatic colon cancer stem cells? / J Clin Invest 118:2021~2024
Fabrizi E / 2010 / Therapeutic implications of colon cancer stem cells / World J Gastroenterol 16:3871~3877
Puglisi M / 2008 / Identification of CD133-cancer stem cells in hepatic metastasis from colon cancer / Gastroenterology 134:A447~A448
Varnat F / 2009 / CD133+cancer stem cells are more prevalent in metastatic than non-metastatic colon carcinomas / Swiss Med Wkly 139:6S
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