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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 68 - 80 (13page)
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G protein-coupled receptors (GPCRs) are a large class of transmembranereceptors categorized into five distinct families:rhodopsin, secretin, adhesion, glutamate, and frizzled. Theybind and regulate 80% of all hormones and account for20-50% of the pharmaceuticals currently on the market.
Hundreds of GPCRs integrate and coordinate the functions ofindividual cells, mediating signaling between various organs.
GPCRs are crucial players in tumor progression, adipogenesis,and inflammation. Several studies have also confirmed theircentral roles in embryonic development and stem cell maintenance.
Recently, GPCRs have emerged as key players in theregulation of cell survival, proliferation, migration, and self-renewalin pluripotent (PSCs) and cancer stem cells (CSCs). Ourstudy and other reports have revealed that the expression ofmany GPCRs is modulated during the generation of inducedPSCs (iPSCs) or CSCs as well as during CSC sphere formation.
These GPCRs may have crucial roles in the regulation of selfrenewaland other biological properties of iPSCs and CSCs.
This review addresses the current understanding of the role ofGPCRs in stem cell maintenance and somatic reprogrammingto PSCs or CSCs.
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참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)]
Callihan P / 2011 / Regulation of stem cell pluripotency and differentiation by G protein coupled receptors / Pharmacol Ther 129 : 290 ~ 306
Cappuccio I / 2005 / Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells / Neuropharmacology 49 (1)
Cappuccio I / 2006 / Contextdependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors / Neuropharmacology 51 : 606 ~ 611
Ciceroni C / 2010 / mGLU3metabotropic glutamate receptors modulate the differentiation of SVZ-derived neural stem cells towards the astrocytic lineage / Glia 58 : 813 ~ 822
Callihan P / 2011 / Regulation of stem cell pluripotency and differentiation by G protein coupled receptors / Pharmacol Ther 129 : 290 ~ 306
Cappuccio I / 2005 / Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells / Neuropharmacology 49 (1)
Cappuccio I / 2006 / Contextdependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors / Neuropharmacology 51 : 606 ~ 611
Ciceroni C / 2010 / mGLU3metabotropic glutamate receptors modulate the differentiation of SVZ-derived neural stem cells towards the astrocytic lineage / Glia 58 : 813 ~ 822
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