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논문 기본 정보

자료유형
학술저널
저자정보
Shota Somekawa (Cardiovascular Center Research Institute) Atsushi Mahara (Cardiovascular Center Research Institute) Kazunari Masutani (Kyoto Institute of Technology) Yoshiharu Kimura (Kyoto Institute of Technology) Hiroshi Urakawa (Kyoto Institute of Technology) Tetsuji Yamaoka (National Cerebral)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제14권 제5호
발행연도
2017.1
수록면
507 - 516 (10page)

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초록· 키워드

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Some gel types have been reported to prevent left ventricular (LV) remodeling in myocardial infarction (MI) animal models. In this study, we tested biodegradable thermoresponsive gels. Poly(L-lactic acid)–poly(ethylene glycol) (PLLA–PEG) and poly(D-lactic acid)–poly(ethylene glycol) (PDLA–PEG) were synthesized by the polycondensation of Land D-lactic acids in the presence of PEG and succinic acid. Each of these block copolymers was used to prepare particles dispersed in an aqueous medium and mixed together to obtain a PLLA–PEG/PDLA–PEG suspension, which was found to show a sol-to-gel transition around the body temperature by the stereocomplex formation of enantiomeric PLLA and PDLA sequences. In the present study, the G0 of the PLLA–PEG/PDLA–PEG suspension in the rheological measurement remained as low as 1 Pa at 20 C and increased 2 kPa at 37 C. The sol–gel systems of PLLA–PEG/PDLA–PEG might be applicable to gel therapy. The effect of the PLLA–PEG/PDLA–PEG gel injection was compared with that of a calciumcrosslinked alginate gel and saline in a rat MI model. The percent fractional shortening improved in the PLLA–PEG/ PDLA–PEG (20.8 ± 4.1%) and alginate gel (21.1 ± 4.8%) compared with the saline (14.2 ± 2.8%) with regard to the echocardiograph 4 weeks after the injection (p\0.05). There were reduced infarct sizes in both PLLA–PEG/PDLA–PEG gel and alginate gel compared with the saline injection (p\0.05). Moreover, a greater reduction in LV cavity area was observed with the PLLA–PEG/PDLA–PEG gel than with the alginate gel (p = 0.06). These results suggest that the PLLA– PEG/PDLA–PEG gel should have high therapeutic potential in gel therapy for LV remodeling after MI.

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