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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 787 - 802 (16page)
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Dysfunction or loss of blood vessel causes several ischemic diseases.Although endothelial progenitor cells (EPCs) are a promising source for cell-based therapy, ischemia-induced pathophysiological condition limits the recovery rate by causing drastic cell death. To overcome this issue, we attempted to develop a cell-targeted peptide delivery and priming system to enhance EPCbased neovascularization using an engineered M13 bacteriophage harboring nanofibrous tubes displaying *2700 multiple functional motifs. The M13 nanofiber was modified by displaying RGD, which is an integrin-docking peptide, on the minor coat protein, and bymutilayering SDKPmotifs,which are the key active sites for thymosin b4, on themajor coat protein. The engineered M13 nanofiber dramatically enhanced ischemic neovascularization by activating intracellular and extracellular processes such as proliferation, migration, and tube formation in the EPCs. Furthermore, transplantation of the primed EPCs with the M13 nanofiber harboring RGD and SDKP facilitated functional recovery and neovascularization in a murine hindlimb ischemia model. Overall, this study demonstrates the effectiveness of theM13 nanofiber-based novel peptide deliveryandprimingstrategy inpromotingEPC bioactivity and neovessel regeneration. To our knowledge, this is first report onM13 nanofibers harboring dual functional motifs, the use of which might be a novel strategy for stem and progenitor cell therapy against cardiovascular ischemic diseases.
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등록된 정보가 없습니다.
참고문헌 (3)
참고문헌 신청
신용철 / 2015 / RGD Peptide-displaying M13 Bacteriophage/PLGA Nanofibers as Cell-adhesive Matrices for Smooth Muscle Cells / Journal of the Korean Physical Society 66(1):12~16
신용철 / 2014 / Cell-adhesive RGD peptide-displaying M13 bacteriophage/PLGA nanofiber matrices for growth of fibroblasts / 생체재료학회지 18(4):114~120
Mark B. Hampton / 2016 / Peroxiredoxins and the Regulation of Cell Death / Molecules and Cells 39(1):72~76
신용철 / 2014 / Cell-adhesive RGD peptide-displaying M13 bacteriophage/PLGA nanofiber matrices for growth of fibroblasts / 생체재료학회지 18(4):114~120
Mark B. Hampton / 2016 / Peroxiredoxins and the Regulation of Cell Death / Molecules and Cells 39(1):72~76
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