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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 51 - 51 (1page)
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PP242 is a second generation novel selective ATP-competitive inhibitor of mTOR that displayed promising anticancer activity over several cancer types by inhibiting both the complexes of mTOR (mTORC1 and mTORC2).
In this study, identification of the possible metabolites and evaluation of pharmacokinetic profile of PP242 in rats were studied. Comprehensive metabolomics and lipidomics investigations were also performed in plasma and tumor tissue to reveal the metabolic mechanism in colon cancer xenograft mouse model.
For the metabolite identification, single dose of PP242 was orally administered in Sprague-Dawley (SD) rat and metabolites were identified in plasma, urine and feces. Comprehensive metabolomics and lipidomics investigations were performed in an LS174T cell-induced colon cancer xenograft mouse model after 3 weeks of PP242 treatment. UPLC-tandem-MS was used for pharmacokinetics for PP242 and profiling of identified metabolites. Ultra-performance chromatography-Orbitrap-mass spectrometry (UPLC- Orbitrap-MS) was used for the metabolites identification and metabolo ... 전체 초록 보기
In this study, identification of the possible metabolites and evaluation of pharmacokinetic profile of PP242 in rats were studied. Comprehensive metabolomics and lipidomics investigations were also performed in plasma and tumor tissue to reveal the metabolic mechanism in colon cancer xenograft mouse model.
For the metabolite identification, single dose of PP242 was orally administered in Sprague-Dawley (SD) rat and metabolites were identified in plasma, urine and feces. Comprehensive metabolomics and lipidomics investigations were performed in an LS174T cell-induced colon cancer xenograft mouse model after 3 weeks of PP242 treatment. UPLC-tandem-MS was used for pharmacokinetics for PP242 and profiling of identified metabolites. Ultra-performance chromatography-Orbitrap-mass spectrometry (UPLC- Orbitrap-MS) was used for the metabolites identification and metabolo ... 전체 초록 보기
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