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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 36 - 43 (8page)
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Purpose: This study investigated the clinicopathological featuresof operable breast cancer lesions located in different hemispheresof the breast and determined related survival outcomes.
Methods: Data from 5,330 patients with invasive ductal carcinomawere retrospectively analyzed based on tumor location. Results:The median follow-up time was 68 months (range, 18–176months). Patients with breast cancer located in the outer hemisphereof the breast had lesions with more advanced nodalstages and more frequently received adjuvant chemotherapythan patients with breast cancer in the inner hemisphere. The5-year disease-free survival (DFS) rates of patients with tumorslocated in outer versus inner hemispheres were 81.5% and77.0%, respectively (p=0.004); the overall survival (OS) rateswere 90.7% and 88.8%, respectively (p<0.001). The associationbetween tumor location and the 5-year DFS rate was most apparentin node-positive patients (73.1% vs. 65.8% for outer vs.
inner hemisphere lesions, p<0.001) and in patients with primarytumors greater than 2 cm in diameter (78.2% vs. 72.3%,p=0.002). Multivariate analysis showed that tumor location wasan independent predictor of DFS (hazard ratio [HR], 1.23;p=0.002) and OS (HR, 1.28; p=0.006). There were no significantdifferences in 5-year DFS or OS rates between patients with outerversus inner hemisphere tumors when internal mammary nodeirradiation was performed. Conclusion: This study demonstratedthat tumor location was an independent prognostic factor foroperable breast cancer. Internal mammary node irradiation isrecommended for patients with breast cancer of the inner hemisphereand positive axillary lymph nodes or large primary tumors
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참고문헌 (15)
참고문헌 신청
Siegel R / 2012 / Cancer treatment and survivorship statistics, 2012 / CA Cancer J Clin 62:220~241
Xue J / 2013 / Predictive factors of brain metastasis in patients with breast cancer / Med Oncol 30:337
정규원 / 2013 / Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010 / Cancer Research and Treatment 45(1):1~14
Hofer S / 2013 / Treatment of breast cancer brain metastases / Eur J Pharmacol 717:84~87
Karam I / 2013 / Population-based outcomes after brain radiotherapy in patients with brain metastases from breast cancer in the Pre-Trastuzumab and Trastuzumab eras / Radiat Oncol 8:12
Xue J / 2013 / Predictive factors of brain metastasis in patients with breast cancer / Med Oncol 30:337
정규원 / 2013 / Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010 / Cancer Research and Treatment 45(1):1~14
Hofer S / 2013 / Treatment of breast cancer brain metastases / Eur J Pharmacol 717:84~87
Karam I / 2013 / Population-based outcomes after brain radiotherapy in patients with brain metastases from breast cancer in the Pre-Trastuzumab and Trastuzumab eras / Radiat Oncol 8:12
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