지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.5
- 발행연도
- 2015.1
- 수록면
- 476 - 482 (7page)
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초록· 키워드
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Purpose: Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation status in patients with chronic urticaria using thrombin generation assay (TGA) and the levels of individual coagulation factors. Methods: Patients with chronic urticaria (n=57) and 20 healthy controls were enrolled. TGA was performed under stimulation with 2 concentrations of tissue factor (TF). Coagulation factors and conventional coagulation assays were also analyzed. Results: Although patients with chronic urticaria showed prolonged activated partial thromboplastin time, prothrombin time did not differ significantly between patients and controls. In both 1 pM and 5 pM TF-stimulated TGA, peak thrombin and endogenous thrombin potential (ETP) levels were markedly decreased in patients with chronic urticaria. As expected, intrinsic coagulation factors (VIII, IX, and XII), as well as coagulation factors of the common pathway (II, V, and X), were consistently decreased. Additionally, D-dimer was significantly increased in patients as compared to controls. In multivariate regression analysis, the presence of chronic urticaria was the only significant independent contributor to the low ETP value. Conclusions: Chronic urticaria is characterized by in vivo coagulation activation through the intrinsic coagulation pathway, which can be measured with sensitivity using TGA.
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참고문헌 (26)
참고문헌 신청
Cugno M / 2012 / Inflammation and coagulation in urticaria and angioedema / Curr Vasc Pharmacol 10:653~658
Cugno M / 2010 / Activation of blood coagulation in chronic urticaria: pathophysiological and clinical implications / Intern Emerg Med 5:97~101
Zuberbier T / 2009 / Bindslev-Jensen C, Walter Canonica G, Church MK, Gimenez-Arnau AM, et al. EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria / Allergy 64:1427~1443
Greaves M / 2000 / Chronic urticaria / J Allergy Clin Immunol 105:664~672
Grattan CE / 1986 / A serological mediator in chronic idiopathic urticaria--a clinical, immunological and histological evaluation / Br J Dermatol 114:583~590
Cugno M / 2010 / Activation of blood coagulation in chronic urticaria: pathophysiological and clinical implications / Intern Emerg Med 5:97~101
Zuberbier T / 2009 / Bindslev-Jensen C, Walter Canonica G, Church MK, Gimenez-Arnau AM, et al. EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria / Allergy 64:1427~1443
Greaves M / 2000 / Chronic urticaria / J Allergy Clin Immunol 105:664~672
Grattan CE / 1986 / A serological mediator in chronic idiopathic urticaria--a clinical, immunological and histological evaluation / Br J Dermatol 114:583~590
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