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Rheumatoid arthritis, the most common form of arthritis, is typically characterized by induced inflammatory pain in joints. Recent studies have reported on the expression of pain receptors such as transient receptor potential vanilloid 1 (TRPV1) and acid sensing ion channel 3 (ASIC3), which are related to pain induction and regulation. This study was conducted to investigate the expression of TRPV1 and ASIC3 in response to the analgesic effect of an arthritis treatment in a collagen-induced arthritis (CIA). Methods. Mice were divided into 3 groups: Control, CIA, and CIA with arthritis treatment. Mice received intraperitoneal injection with 10 mg/kg infliximab and 10 mg/kg meloxicam five times per week for 3 weeks. Mechanical hyperalgesia, histologic examination of the feet, serum levels of inflammatory cytokine such as interleukin-6 (IL-6), and interleukin-17 (IL-17), TRPV1 and ASIC3 expression were investigated. Results. The serum levels of IL-6 and IL-17 were lower in the treatment group (73.77±10.11 pg/mL and 26.75±7.17 pg/mL, respectively) compared to the CIA group (p＜0.001). Histological analysis showed decreased synovial cell proliferation, leukocyte infiltration, and cartilage destruction in the treatment group compared with the CIA group. The CIA group that underwent arthritis treatment showed a significantly increased withdrawal threshold of mechanical nociception on the hind paw and increased expression of TRPV1 and ASIC3 compared to the CIA group. Conclusion. Arthritis treatment resulted in an anti-inflammatory and analgesic effect through upregulation of the activity of TRPV1 and ASIC3 in CIA mice.
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참고문헌 (24)
참고문헌 신청
Choy EH. / 2001 / Cytokine pathways and joint inflammation in rheumatoid arthritis / N Engl J Med 344:907~916
Watkins LR. / 1995 / Immune activation : the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states / Pain 63:289~302
Kojima M. / 2009 / Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis / J Psychosom Res 67:425~431
Billeter AT. / 2014 / Transient receptor potential ion channels : powerful regulators of cell function / Ann Surg 259:229~235
Mamet J. / 2002 / Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels / J Neurosci 22:10662~10670
Watkins LR. / 1995 / Immune activation : the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states / Pain 63:289~302
Kojima M. / 2009 / Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis / J Psychosom Res 67:425~431
Billeter AT. / 2014 / Transient receptor potential ion channels : powerful regulators of cell function / Ann Surg 259:229~235
Mamet J. / 2002 / Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels / J Neurosci 22:10662~10670
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