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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 997 - 1,006 (10page)
- DOI
- https://doi.org/10.3803/EnM.2021.1167
이용수
초록· 키워드
오류제보하기
Background: Intracellular calcium (Ca2+) homeostasis plays an essential role in adipocyte metabolism and its alteration is associatedwith obesity and related disorders. Transient receptor potential vanilloid 4 (TRPV4) channels are an important Ca2+ pathway in adipocytes and their activity is regulated by metabolic mediators such as insulin. In this study, we evaluated the role of TRPV4 channelsin metabolic activity and adipokine secretion in human white adipocytes.
Methods: Human white adipocytes were freshly cultured and the effects of the activation and inhibition of TRPV4 channels on lipolysis, glucose uptake, lactate production, and leptin and adiponectin secretion were evaluated.
Results: Under basal and isoproterenol-stimulated conditions, TRPV4 activation by GSK1016709A decreased lipolysis whereasHC067047, an antagonist, increased lipolysis. The activation of TRPV4 resulted in increased glucose uptake and lactate productionunder both basal conditions and insulin-stimulated conditions; in contrast HC067047 decreased both parameters. Leptin productionwas increased, and adiponectin production was diminished by TRPV4 activation and its inhibition had the opposite effect.
Conclusion: Our results suggested that TRPV4 channels are metabolic mediators involved in proadipogenic processes and glucosemetabolism in adipocyte biology. TRPV4 channels could be a potential pharmacological target to treat metabolic disorders.
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등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Cifuentes M / 2008 / Antilipolytic effect of calcium-sensing receptor in human adipocytes / Mol Cell Biochem 319:17~21
Cammisotto PG / 2004 / Role of calcium in the secretion of leptin from white adipocytes / Am J Physiol Regul Integr Comp Physiol 287:R1380~6
Sukumar P / 2012 / Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin / Circ Res 111:191~200
Goudarzi F / 2018 / The role of calcium in differentiation of human adipose-derived stem cells to adipocytes / Mol Biotechnol 60:279~289
Schlottmann I / 2014 / Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes / Int J Obes(Lond) 38:1221~1227
Cammisotto PG / 2004 / Role of calcium in the secretion of leptin from white adipocytes / Am J Physiol Regul Integr Comp Physiol 287:R1380~6
Sukumar P / 2012 / Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin / Circ Res 111:191~200
Goudarzi F / 2018 / The role of calcium in differentiation of human adipose-derived stem cells to adipocytes / Mol Biotechnol 60:279~289
Schlottmann I / 2014 / Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes / Int J Obes(Lond) 38:1221~1227
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