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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 119 - 126 (8page)
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초록· 키워드
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Activation of transient receptor potential vanilloid 1 (TRPV1), a calcium permeable channel expressed in primary sensory neurons, induces the release of glutamate from their central and peripheral afferents during normal acute and pathological pain. However, little information is available regarding the glutamate release mechanism associated with TRPV1 activation in primary sensory neurons. To address this issue, we investigated the expression of vesicular glutamate transporter (VGLUT) in TRPV1-immunopositive (+) neurons in the rat trigeminal ganglion (TG) under normal and complete Freund’s adjuvant (CFA)-induced inflammatory pain conditions using behavioral testing as well as double immunofluorescence staining with antisera against TRPV1 and VGLUT1 or VGLUT2. TRPV1 was primarily expressed in small and medium-sized TG neurons. TRPV1+ neurons constituted approximately 27% of all TG neurons. Among all TRPV1+ neurons, the proportion of TRPV1+ neurons coexpressing VGLUT1 (VGLUT1+/ TRPV1+ neurons) and VGLUT2 (VGLUT2+/TRPV1+ neurons) was 0.4% ± 0.2% and 22.4% ± 2.8%, respectively.
The proportion of TRPV1+ and VGLUT2+ neurons was higher in the CFA group than in the control group (TRPV1+ neurons: 31.5% ± 2.5% vs. 26.5% ± 1.2%, VGLUT2+ neurons: 31.8% ± 1.1% vs. 24.6% ± 1.5%, p < 0.05), whereas the proportion of VGLUT1+, VGLUT1+/TRPV1+, and VGLUT2+/TRPV1+ neurons did not differ significantly between the CFA and control groups. These findings together suggest that VGLUT2, a major isoform of VGLUTs, is involved in TRPV1 activation-associated glutamate release during normal acute and inflammatory pain.
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참고문헌 (30)
참고문헌 신청
Caterina MJ / 1997 / The capsaicin receptor : a heat-activated ion channel in the pain pathway / Nature 389:816~824
Tominaga M / 1998 / The cloned capsaicin receptor integrates multiple pain-producing stimuli / Neuron 21:531~543
Guo A / 1999 / Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites / Eur J Neurosci 11:946~958
Valtschanoff JG / 2001 / Vanilloid receptor VR1 is both presynaptic and postsynaptic in the superficial laminae of the rat dorsal horn / J Comp Neurol 436:225~235
Bae YC / 2004 / Expression of vanilloid receptor TRPV1 in the rat trigeminal sensory nuclei / J Comp Neurol 478:62~71
Tominaga M / 1998 / The cloned capsaicin receptor integrates multiple pain-producing stimuli / Neuron 21:531~543
Guo A / 1999 / Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites / Eur J Neurosci 11:946~958
Valtschanoff JG / 2001 / Vanilloid receptor VR1 is both presynaptic and postsynaptic in the superficial laminae of the rat dorsal horn / J Comp Neurol 436:225~235
Bae YC / 2004 / Expression of vanilloid receptor TRPV1 in the rat trigeminal sensory nuclei / J Comp Neurol 478:62~71
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