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Comparative analysis of NRF2-responsive gene expression in AcPC-1 pancreatic cancer cell line
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논문 기본 정보

Type
Academic journal
Author
Journal
한국유전학회 Genes & Genomics Genes & Genomics Vol.37 No.1 KCI Accredited Journals
Published
2015.1
Pages
97 - 109 (13page)

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Comparative analysis of NRF2-responsive gene expression in AcPC-1 pancreatic cancer cell line
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NRF2 is a nuclear transcription factor activatedin response to oxidative stress and related with metabolizingof xenotoxic materials and ABC transporter mediateddrug resistance. We studied the expression of mRNAsunder the siRNA-mediated knockdown of NRF2 andtBHQ-treated condition in AsPC-1 metastatic pancreaticcancer cell line to understand the AsPC-1 specific role(s) ofNRF2 and further to investigate the relationship betweendrug resistance and metastatic plasticity and mobility ofAsPc1. Here we show that the genes of aldo–keto reductases,cytochrome P450 family, aldehyde dehydrogenase,thioredoxin reductase, ABC transporter and epoxidehydrolase responsible for drug metabolism or oxidativestress concisely responded to NRF2 stabilization andknockdown of NRF2. In addition the expression of PIR, acandidate of oncogene and KISS1, a suppressor of metastasiswere affected by NRF2 stabilization and knockdown. Our result provide comprehensive understanding of NRF2target genes of drug response, oxidative stress response andmetastasis in AsPc-1 metastatic pancreatic cancer cell line.
#NRF2 #tBHQ #AsPC-1 #Pancreatic cancer #Oxidative stress #Drug metabolism

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References (63)

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Acharya A / 2010 / Redox regulation in cancer: a double-edged sword with therapeutic potential / Oxid Med Cell Longev 3:23~34 google schola Adachi T / 2007 / Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress / J Exp Ther Oncol 6:335~348 google schola Agyeman AS / 2012 / Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles / Breast Cancer Res Treat 132:175~187 google schola Arlt A / 2013 / Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity / Oncogene 32:4825~4835 google schola Banning A / 2005 / The GI-GPx gene is a target for Nrf2 / Mol Cell Biol 25:4914~4923 Crossref

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