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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 213 - 221 (9page)
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Mesenchymal stem cells (MSCs) secrete neurotrophicfactors, and have been reported to improvefunctional outcomes in animal models of neurodegenerativediseases such as cerebral ischemia, stroke, spinal cordlesions, and Parkinson’s disease. Previously, we found thatadipose tissue-derived mesenchymal stem cells (ASCs)cultured at high cell density (HD-ASCs) expressed interferon-beta (IFN-b). Here we demonstrate that ASCsexpressing IFN-b also express brain-derived neurotrophicfactor (BDNF). Growth rates of neuroblastoma cells (SKN-BE(2)C) were increased when co-cultured with HDASCsor treated with concentrated medium obtained fromHD-ASCs (HD-ASC-CM). The HD-ASC-CM inducedAKT phosphorylation in SK-N-BE(2)C cells, and AKTinhibition by Ly294002 reduced cell viability of SK-NBE(2)C cells. Additionally, a protective effect on SK-NBE(2)C cells exposed to 6-hydroxydopamine (6-OHDA)was observed in the HD-ASC-CM or brain-derived neurotrophicfactor (BDNF) treated cells. The protective effectof the HD-ASC-CM was neutralized by anti-BDNF antibody.
In the 6-OHDA-induced Parkinson’s disease ratmodel, ASCs reduced amphetamine-induced rotations anda greater number of tyrosine hydroxylase (TH)-positivecells were observed in the HD-ASCs-injected group comparedwith sham controls and the low density culturedASC-injected group. Moreover, the expression of BDNF,nerve growth factor (NGF), TH, and proliferating cellnuclear antigen (PCNA) in ipsilateral midbrain tissuesincluding substantia nigra pars compacta (SNc) wasincreased by transplantation of HD-ASCs. These dataindicate that HD-ASCs may induce neuroprotective effectsthrough BDNF expression and subsequent increase of proliferation in neuronal cells both in vitro and in vivo.
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참고문헌 (34)
참고문헌 신청
Ambjorn M / 2013 / IFNB1/interferon-beta-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function / Autophagy 9:287~302
Azoulay D / 2009 / Interferon-beta therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism / J Neuroimmunol 211:114~119
Biernacki K / 2005 / Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis / Arch Neurol 62:563~568
Borden EC / 2007 / Interferons at age 50: past, current and future impact on biomedicine / Nat Rev Drug Discov 6:975~990
Bouchez G / 2008 / Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson’s disease / Neurochem Int 52:1332~1342
Azoulay D / 2009 / Interferon-beta therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism / J Neuroimmunol 211:114~119
Biernacki K / 2005 / Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis / Arch Neurol 62:563~568
Borden EC / 2007 / Interferons at age 50: past, current and future impact on biomedicine / Nat Rev Drug Discov 6:975~990
Bouchez G / 2008 / Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson’s disease / Neurochem Int 52:1332~1342
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