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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 241 - 246 (6page)
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An increase in resistance to antibiotics inPseudomonas aeruginosa has become a major worldwideconcern. Particularly, P. aeruginosa which produces carbapenemases,versatile metallo-b-lactamases (MBLs),causes limitation to treat infection. Class I integrons playan important role in the spread of antibiotic resistancedeterminants such as MBLs in P. aeruginosa. In thepresent study, we identified and characterized geneticcontents of class I integrons in P. aeruginosa DK45 thatwas isolated from catheterized urine of patients atChungbuk National University Hospital in South Koreaand strongly exhibited carbapenemase activity. The correlationbetween integron-associated gene cassettes andantibiotics resistance was also investigated. Screening ofthe integrons in P. aeruginosa was performed by PCR andthe integron-associated gene cassettes were further characterizedby DNA sequencing. It was confirmed that threeintegrons (class I) harboring VIM-2, OXA-10, and OXA-30 type b-lactamase genes, respectively, existed on thebacterial plasmid. Each integron also contained genesencoding resistance determinants to various antibioticssuch as aminoglycoside, fluoroquinolone and folate pathwayinhibitors. Functional analysis by recombinant plasmidsbearing each integron in Escherichia coli indicatedthat each integron was associated to a high resistance rateto b-lactam and aminoglycoside antibiotics. The combinedresults suggest that genetic diversity of class I integrons is amajor factor capable of increasing a broad spectrumresistance to the antibiotics.
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참고문헌 (16)
참고문헌 신청
Bonomo RA / 2006 / Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa / Clin Infect Dis 43(Suppl. 2):S49~S56
Breidenstein EBM / 2011 / Pseudomonas aeruginosa: all roads lead to resistance / Trends Microbiol 19:419~426
Chang CY / 2009 / Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan / Diagn Microbiol Infect Dis 65:214~216
Crowder MW / 2006 / Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria / Acc Chem Res 39:721~728
Fluit AC / 1999 / Class 1 integrons, gene cassettes, mobility, and epidemiology / Eur J Clin Microbiol Infect Dis 18:761~770
Breidenstein EBM / 2011 / Pseudomonas aeruginosa: all roads lead to resistance / Trends Microbiol 19:419~426
Chang CY / 2009 / Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan / Diagn Microbiol Infect Dis 65:214~216
Crowder MW / 2006 / Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria / Acc Chem Res 39:721~728
Fluit AC / 1999 / Class 1 integrons, gene cassettes, mobility, and epidemiology / Eur J Clin Microbiol Infect Dis 18:761~770
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