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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 80 - 89 (10page)
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Ever since a technology to reprogram somatic cells into pluripotent stem cells was developed by Dr.
Shinya Yamanaka’s group in 2006, its therapeutic potential has been extensively discussed. We now call the reprogrammedembryonic stem cell (ESC)-like cell an ‘induced pluripotent stem cell’ (iPSC). The beauty and power ofthe iPS in human case is that it avoids many ethical issues, in that unlike human ESCs (hESCs), iPSCs do not requiredestroying a human embryo to establish pluripotent cell lines. The iPSC holds many hopes that many human diseasesmay be treatable in the near future. On the other hand, there are still several issues that need to be solved priorto the therapeutic use of iPSCs in humans directly. The biggest hurdle is that, so far, there is lack of ways to completelyexclude tumorigenic iPSC-derived cells. Additionally, there is an issue that immune rejection may occur,even in autologously grafted iPSCs, as was observed in monkey experiment. Nevertheless, iPSCs, combined withgenetic manipulation, hold much promise that iPSCs may be used in cell therapy procedures and as tools for investigatingunderlying mechanisms of human diseases. This review will discuss recent progress in cellular reprogrammingand its potential use in regenerative medicine.
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참고문헌 (107)
참고문헌 신청
K Takahashi / 2006 / Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors / Cell 126:663
K Takahashi / 2007 / Induction of pluripotent stem cells from adult human fibroblasts by defined factors / Cell 131:861
J Liao / 2009 / Generation of induced pluripotent stem cell lines from adult rat cells / Cell Stem Cell 4:11
A Honda / 2010 / Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine / J Biol Chem 285:31362
H. Liu / 2008 / P Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts / Cell Stem Cell 3:587
K Takahashi / 2007 / Induction of pluripotent stem cells from adult human fibroblasts by defined factors / Cell 131:861
J Liao / 2009 / Generation of induced pluripotent stem cell lines from adult rat cells / Cell Stem Cell 4:11
A Honda / 2010 / Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine / J Biol Chem 285:31362
H. Liu / 2008 / P Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts / Cell Stem Cell 3:587
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