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논문 기본 정보

자료유형
학술저널
저자정보
Jeong Yoon Lee (The University of Suwon) Sohyuk Kim (The University of Suwon) Seokho Kim (The University of Suwon) Jong Han Kim (Korea Ginseng) Bong Seok Bae (Korea Ginseng) Gi-Bang Koo (Korea Ginseng) Jeongmin Lee (Kyung Hee University) Yoo-Hyun Lee (The University of Suwon)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.46 No.3
발행연도
2022.5
수록면
473 - 480 (8page)

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Background: Benign prostatic hyperplasia (BPH) is a disease characterized by abnormal proliferation of the prostate, which occurs frequently in middle-aged men. In this study, we report the effect of red ginseng oil (KGC11o) on BPH.
Methods: The BPH-induced Sprague-Dawley rats were divided into seven groups: control, BPH, KGC11o 25, 50, 100, 200, and finasteride groups. KGC11o and finasteride were administered for 8 weeks. The BPH biomarkers, DHT, 5AR1, and 5AR2, androgen receptor, prostate-specific antigen (PSA), Bax, Bcl-2, and TGF-b were determined in the serum and prostate tissue. The cell viability after KGC11o treatment was determined using BPH-1 cells, and, androgen receptor, Bax, Bcl-2, and TGF-b were confirmed by western blotting.
Results: In the in vivo study, administration of KGC11o reduced prostate weight by 18%, suppressed DHT (up to 22%) and 5AR2 (up to 12%) levels from administration of 100 mg/kg KGC11o (P < 0.05). PSA was significantly downregulated dose-dependently from at the concentration of 50 mg/kg KGC11o (P < 0.05). BPH-1 cell viability significantly reduced through the treatment with KGC11o. In vitro and vivo, AR, Bcl-2 TGF-b levels reduced significantly but Bax was increased (P < 0.05).
Conclusion: These results suggest that KGC11o may inhibit the development of BPH by significantly reducing the levels of BPH biomarkers via 5ARI, anti-androgenic effect, and anti-proliferation effect, serving as a potential functional food for treating BPH.

목차

abstract
1. Introduction
2. Material and methods
3. Results
4. Discussion
References

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