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논문 기본 정보

자료유형
학술저널
저자정보
Geum-Lan Hong (Chungnam National University) Kyung-Hyun Kim (Chungnam National University) Shanika Karunasagara (Chungnam National University) Ju-Young Jung (Chungnam National University)
저널정보
대한체질인류학회 해부·생물인류학 해부·생물인류학 제33권 제4호
발행연도
2020.12
수록면
181 - 191 (11page)

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Benign prostatic hyperplasia (BPH) is disease characterized by abnormal prostate cell proliferation. Rat models of testosterone propionate (TP)-induced BPH are the most popular experimental models for studying BPH. In rats, the prostate is located below the base of the urinary bladder and comprises four distinct lobes - ventral, lateral, dorsal, and anterior. Autophagy associated with cellular homeostasis has been studied in relation to BPH. Microtubule-associated proteins 1A/1B-light chain 3 (LC3B) and sequestosome 1 (p62) are key markers of autophagy flux. However, the expression and localization of LC3B and p62 have not been elucidated in rats with testosterone-induced BPH. This study investigated the expression and specific localization of the two autophagy markers mentioned. Fifteen Sprague-Dawley rats were classified into three groups: normal control (N.C.), BPH (TP 5 mg/kg), and Fina (TP+finasteride 10 mg/kg). To evaluate the expression of the autophagy markers in BPH, hematoxylin and eosin staining and immunohistochemistry were performed for LC3B and p62. Both LC3B expression and p62 expression were higher in the anterior lobe than other areas. In addition, there was no significant difference in the dorsal lobe LC3B expression among the N.C., BPH, and Fina groups. In the lateral lobe, LC3B expression was decreased in the BPH group and increased in the Fina group. p62 expression in the BPH and Fina groups increased compared to that in the N.C. group. In the ventral lobe of the prostate, LC3B expression was lower in the BPH group, whereas it was higher in the Fina group. On the other hand, p62 expression increased in the BPH group, whereas it was lower in the Fina group similar to those observed in the N.C. group. Autophagy was suppressed in the BPH group, whereas it was induced in the ventral lobe in the Fina group. Based on our finding, we suggest that autophagy is a critical process in BPH. In particular, the ventral lobe of the rat prostate could be a potential target site for evaluating the therapeutic effects of BPH treatment in animal models.
#Localization #Autophagy #LC3 #p62 #Benign prostatic hyperplasia

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
DISCUSSION
REFERENCES

참고문헌 (44)

참고문헌 신청
Roehrborn CG / 2005 / Benign prostatic hyperplasia: an overview / Rev Urol. 7(Suppl 9):S3~S14 google schola Djavan B. / 2003 / Lower urinary tract symptoms/benign prostatic hyperplasia: fast control of the patient’s quality of life / Urology 62(3 Suppl 1):6~14 google schola Scolnik MD / 1994 / Comparative study of experimentally induced benign and atypical hyperplasia in the ventral prostate of different rat strains / J Androl 15:287~297 google schola Shirai T / 2000 / Experimental prostate carcinogenesis-rodent models / Mutat Res-Rev Mutat 462:219~226 google schola Shirai T / 2008 / Significance of chemoprevention for prostate cancer development : Experimental in vivo approaches to chemoprevention / Pathol Int 58:1~16 google schola

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