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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제18권 제3호
- 발행연도
- 2017.9
- 수록면
- 108 - 112 (5page)
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초록· 키워드
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The lower urinary tract symptoms (LUTS) show in benign prostatic hyperplasia (BPH). The three major micturition centers in brain are pontine micturition center (PMC), ventrolateral periaqueductal gray (vlPAG), and medial preopticnucleus (MPA) regions. Previous study showed that c-Fos expression change was associated with LUTS. In present study, the effect of P. ginseng on c-Fos expression in PMC, vlPAG, and MPA regions in rat brain was tested. P. ginseng is the four year-old Korean ginseng. It was collected at the department of medicinal crop research (Eumsung-gun, Chungbuk, Korea) in September 2010. The four groups (n = 6) are control group, BPH-induced group, BPH-induced and P. ginseng-treated group, and BPH-induced and finasteride-treated group. BPH in rats was induced by testosterone. After 4 weeks, all animals were sacrificed to evaluate c-Fos expression in PMC, vlPAG, and MPA regions in rat brain. The c-Fos expression was evaluated in the regions of rat brain by immunohistochemistry (IHC). Present results showed that c-Fos expressions in PMC, vlPAG, and MPA regions in brain of rats in the BPH-induced group were higher compared to c-fos expression of the control group. The increased c-Fos expression in three regions (PMC, vlPAG, and MPA) were decreased by treatment with P. ginseng (200 mg/kg). These results suggest that P. ginseng has an inhibitory effect on the symptoms of BPH and is associated with regulation of c-Fos expression in the brain in a testosterone induced BPH rat model.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Wang HH / 2015 / Characterization of autoimmune inflammation induced prostate stem cell expansion / The Prostate 75:1620~1631
Porcaro AB / 2014 / Chronic inflammation of the prostate type IV with respect to risk of prostate cancer / Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia 86:208~211
Rodrigues MM / 2013 / Role of adhesion molecules and proliferation hyperplasic, pre neoplastic and neoplastic lesions in canine prostate / Pakistan journal of biological sciences (PJBS) 16:1324~1329
Nickel JC / 2006 / The overlapping lower urinary tract symptoms of benign prostatic hyperplasia and prostatitis / Current opinion in urology 16:5~10
Enatsu N / 2016 / Effects of dutasteride on serum free-testosterone and clinical significance of testosterone changes / Andrologia 48:1195~1201
Porcaro AB / 2014 / Chronic inflammation of the prostate type IV with respect to risk of prostate cancer / Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia 86:208~211
Rodrigues MM / 2013 / Role of adhesion molecules and proliferation hyperplasic, pre neoplastic and neoplastic lesions in canine prostate / Pakistan journal of biological sciences (PJBS) 16:1324~1329
Nickel JC / 2006 / The overlapping lower urinary tract symptoms of benign prostatic hyperplasia and prostatitis / Current opinion in urology 16:5~10
Enatsu N / 2016 / Effects of dutasteride on serum free-testosterone and clinical significance of testosterone changes / Andrologia 48:1195~1201
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