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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 28 - 39 (12page)
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This study investigated the effect of snail extract on the growth parameters of old female rats (27 weeks). Rats were administered orally with snail extract at a dose of 100 mg/kg, 200 mg/kg, chondroitin sulfate 10 mg/kg and 0.9% saline (control) for 8 weeks. Bone mineral density (BMD) and serum concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) were significantly higher in rats exposed to snail extract for 8 weeks. MG-63 cells (human osteoblast-like cells) were treated with snail extract for 48 h. Their differentiation and proliferation was investigated with Western blot and morphological changes observed via immunofluorescence staining of β-catenin. Treatment with snail extract significantly increased the levels of growth factors including β-catenin and IGF-1. The snail extract affected osteoblast formation. Morphological changes in MG-63 cells were observed via immunofluorescence staining. Treatment with snail extract increased the expression of β-catenin in MG-63 cells. Results suggest that the treatment of MG-63 cells with snail extract increased the longitudinal growth and growth factor levels. Snail extract may be pharmacologically effective in osteo-genic differentiation in vitro and represents a potential therapeutic agent for bone formation.
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참고문헌 (25)
참고문헌 신청
김윤미 / 2015 / 골다공증 유병률, 인지율, 치료율 및 영향요인의 성별 비교: 국민건강영양조사 자료(2008~2011년) 활용 / Journal of Korean Academy of Nursing 45(2):293~305
NIH osteoporosis. / 2015 / Osteoporosis: Peak Bone Mass in Women
대한골다공증학회 / 2015 / 골다공증 치료지침
Leftwic, A. W. / 1977 / A dictionary of zoology, 450 / Constable and company limited
권오길 / 1993 / 원색한국패류도감, 177 / 아카데미서적
NIH osteoporosis. / 2015 / Osteoporosis: Peak Bone Mass in Women
대한골다공증학회 / 2015 / 골다공증 치료지침
Leftwic, A. W. / 1977 / A dictionary of zoology, 450 / Constable and company limited
권오길 / 1993 / 원색한국패류도감, 177 / 아카데미서적
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