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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 182 - 187 (6page)
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초록· 키워드
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Many plant derived phytochemicals have been considered as the main therapeutic strategy against Alzheimer’s disease (AD). AD is a progressive neurodegenerative disorder, and the most predominant cause of dementia in the elderly. Cholinergic deficit, senile plaque/β-amyloid (Aβ) peptide deposition and oxidative stress have been identified as three main pathogenic pathways which contribute to the progression of AD. We screened many different plant species for their effective use in both modern and traditional system of medicines. In this study, we tested that MeOH extract of the stem bark of Hopea chinensis (Merr.) Hand.-Mazz. (HCM) affects on the processing of Amyloid precursor portein (APP) from the APPswe overexpressing Neuro2a cell line. We showed that HCM reduced the secretion level of Aβ42 and Aβ40 in a dose dependent manner. We found that HCM increased over 1.5 folds of the secretion level of sAPPα, a metabolite of α-secretase. Furthermore, we found that HCM inhibited acetylcholinesterase activity in vitro. We suggest that the stem bark of Hopea chinensis may be a useful source to develop a therapeutics for AD.
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참고문헌 (31)
참고문헌 신청
0000 / 통계청 자료
Morris, J. C. / 1996 / Classification of dementia and Alzheimer's disease / Acta Neurol. Scand. 165:41~50
Selkoe, D. J. / 1998 / The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease / Trends Cell Biol 8:447~453
Strittmatter, W. J. / 1993 / Binding of human apolipoprotein E to synthetic amyloid beta peptide isoform-specific effects and implications for late-onset Alzheimer disease / Proc. Natl. Acad. Sci. USA 90:8098~8102
Corder, E. H. / 1993 / Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families / Science 261:921~923
Morris, J. C. / 1996 / Classification of dementia and Alzheimer's disease / Acta Neurol. Scand. 165:41~50
Selkoe, D. J. / 1998 / The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease / Trends Cell Biol 8:447~453
Strittmatter, W. J. / 1993 / Binding of human apolipoprotein E to synthetic amyloid beta peptide isoform-specific effects and implications for late-onset Alzheimer disease / Proc. Natl. Acad. Sci. USA 90:8098~8102
Corder, E. H. / 1993 / Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families / Science 261:921~923
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