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자료유형
학술저널
저자정보
Jae-Hwan Choi (IN2BIO) Bora Kim (Mokwon University)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.27 No.4
발행연도
2021.12
수록면
300 - 306 (7page)
DOI
10.20307/nps.2021.27.4.300

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초록· 키워드

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Chronic ultraviolet (UV) radiation causes photoaging, which represents skin damage, disrupts skin barrier function, and promotes wrinkle formation. We investigated that the polysaccharide extract of an edible basidiomycetous white jelly mushroom, Tremella fuciformis, (TF-Glucan<SUP>®</SUP>) exhibited statistically photoprotective activity by inhibiting matrix metalloproteases (MMPs) and increasing collagen synthesis, and an antiinflammatory activity by inhibiting nitric oxide and pro-inflammatory cytokines at the concentrations of less than 1000 μg/ml, which is not cytotoxic (p < 0.05). Additionally, TF-Glucan<SUP>®</SUP> increased the expression of involucrin and filaggrin to prevent the disruption of UVB-induced barrier function (p < 0.05). TF-Glucan<SUP>®</SUP> was assessed as a safe material by the human primary skin irritation (1, 3, 5%), human repeated insult patch test (no sensitization at 5%), 3T3 NRU phototoxicity assay (no phototoxicity, PIF < 2, MPE < 0.1), eye irritation test test by BCOP (no category, IVIS ≤ 3) and local lymph node assay (negative at 10, 25, 50%) for identifying potential skin sensitizing. These results suggest that TF-Glucan<SUP>®</SUP> may be useful as an anti-photoaging ingredient for developing cosmeceuticals.

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Abstract
Introduction
Experimental
Results and Discussion
References

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