지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제7호
- 발행연도
- 2016.1
- 수록면
- 3,025 - 3,033 (9page)
이용수
초록· 키워드
오류제보하기
Chronic myeloid leukaemia (CML) is a clonal myeloproliferative hematopoietic stem cell disorder. Deregulated BCR-ABL fusion tyrosine kinase activity is the main cause of CML disease pathogenesis, making BCR-ABL an ideal target for inhibition. Current tyrosine kinase inhibitors (TKIs) designed to inhibit BCR-ABL oncoprotein activity, have completely transformed the prognosis of CML. Interruption of TKI treatment leads to minimal residual disease reside (MRD), thought to reside in TKI-insensitive leukaemia stem cells which remain a potential reservoir for disease relapse. This highlights the need to develop new therapeutic strategies for CML either as small molecule master TKIs or phytopharmaceuticals derived from nature to achieve chronic molecular remission. This review outlines the past, present and future therapeutic approaches for CML including coverage of relevant mechanisms, whether ABL dependent or independent, and epigenetic factors responsible for developing resistance against TKIs. Appearance of mutant clones along the course of therapy either pre-existing or induced due to therapy is still a challenge for the clinician. A proposed in-vitro model of generating colony forming units from CML stem cells derived from diagnostic samples seems to be achievable in the era of high throughput technology which can take care of single cell genomic profiling.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical Approach
대한암예방학회지
2017 .01
-
An Overview and Update of Chronic Myeloid Leukemia for Primary Care Physicians
Korean Journal of Family Medicine
2015 .01
-
Chronic Myeloid Leukemia - Prognostic Value of Mutations
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Chronic Myeloid Leukemia With Rare Variant b2a3 (e13a3) BCR-ABL1 Fusion
Annals of Laboratory Medicine
2016 .01
-
Concurrence of e1a2 and e19a2 BCR-ABL1 Fusion Transcripts in a Typical Case of Chronic Myeloid Leukemia
Annals of Laboratory Medicine
2017 .01
-
Treatment after failure of frontline therapy of chronic myeloid leukemia in chronic phase including allogeneic hematopoietic stem cell transplantation
Blood Research
2023 .04
-
Asciminib: the first-in-class allosteric inhibitor of BCR::ABL1 kinase
Blood Research
2023 .04
-
Chronic myeloid leukemia: a type of MPN
Blood Research
2022 .06
-
Evaluation of a new flow cytometry based method for detection of BCR-ABL1 fusion protein in chronic myeloid leukemia
Blood Research
2017 .01
-
A narrative review on adverse effects of dasatinib with a focus on pharmacotherapy of dasatinib-induced pulmonary toxicities
Blood Research
2021 .12
-
A case of e1a2 (minor, P190) BCR-ABL1-positive chronic myeloid leukemia in Korea
Blood Research
2021 .12
-
Concomitant AID Expression and BCL7A Loss Associates With Accelerated Phase Progression and Imatinib Resistance in Chronic Myeloid Leukemia
Annals of Laboratory Medicine
2017 .01
-
Treatment-free remission after discontinuation of imatinib, dasatinib, and nilotinib in patients with chronic myeloid leukemia
Blood Research
2023 .04
-
Minor BCR-ABL1-Positive Acute Myeloid Leukemia Associated With the NPM1 Mutation and FLT3 Internal Tandem Duplication
Annals of Laboratory Medicine
2016 .01
-
High rate of hepatitis B reactivation during tyrosine kinase inhibitor treatment among patients with chronic myeloid leukemia in Korea
Blood Research
2022 .12
-
만성골수성백혈병의 타이로신인산화효소 억제제 치료 중 발생하는 혈관합병증
대한의사협회지
2023 .04
-
The rs61764370 Functional Variant in the KRAS Oncogene is Associated with Chronic Myeloid Leukemia Risk in Women
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
A Novel e8a2BCR-ABL1 Fusion Transcript without Insertion Sequence in a Patient with Chronic Myeloid Leukemia
Annals of Laboratory Medicine
2018 .01
-
A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement
Annals of Laboratory Medicine
2017 .01
-
Detection of BCR/ABL Fusion Gene by Hematological and Cytogenetical Analysis in Chronic Myeloid Leukemia Patients in Quetta, Pakistan
Asian Pacific journal of cancer prevention : APJCP
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0