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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.3
- 수록면
- 42 - 48 (7page)
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In order to maintain bone homeostasis, it is necessary to balance bone resorption and remodeling through the differentiation of osteoclasts that absorb old bone and osteoblasts that form new bone. However, bone resorption due to excessive osteoclast differentiation is a major cause of osteoporosis and controlling excessive osteoclast differentiation has been known as a treatment strategy for osteoporosis. Therefore, in this study, the effect of an ethanol extract of Sphaerotylus antarcticus Kirkpatrick, 1907 (SAE), polar-derived sponge with unknown biological activity, on the osteoclast differentiation process of RANKL-induced RAW264.7 cells and the generated ROS was evaluated. In the study results, SAE down-regulated the formation and function of RANKL-induced osteoclasts and osteoclast differentiation specific proteins, genes in a concentration-dependent manner. In addition, it was possible to confirm the result of restoring the lost antioxidant enzyme along with downregulation of ROS generated by RANKL. Therefore, in this study, we propose the possibility of SAE as a potential regulator of osteoporosis due to excessive osteoclast differentiation and report the biological value of the diversity of marine-derived natural products by identifying the first biological activity against SAE that is not yet known.
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Abstract
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결과 및 고찰
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참고문헌 (20)
참고문헌 신청
Warren, J. T., Zou, W., Decker, C. E., Rohatgi, N., Nelson, C. A., Fremont, D. H. and Teitelbaum, S. L. (2015) Correlating RANK ligand/RANK binding kinetics with osteoclast formation and function. J. Cell Biochem. 11: 2476-2483.
Novack, D. V. and Teitelbaum, S. L. (2008) The osteoclast: friend or foe. Annu. Rev. Pathol. 3: 457-484.
Geng, H., Chang, Y. N. and Bai, X. (2017) Fullerenol nano particle ssuppress RANKL?induced osteoclastogenesis by inhibiting differentiation and maturation. Nanoscale 34: 12516-12523.
Teitelbaum, S. L. and Ross, F. P. (2003) Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 8: 638-649.
Sakae, T., Ichiro, N., Jun-Ichiro, I., Hiromi, O. and Kozo, N. (2003) Signal transduction pathway regulating osteoclast differentiation and function. J. Bone. Miner. Metab. 21: 123-133.
Novack, D. V. and Teitelbaum, S. L. (2008) The osteoclast: friend or foe. Annu. Rev. Pathol. 3: 457-484.
Geng, H., Chang, Y. N. and Bai, X. (2017) Fullerenol nano particle ssuppress RANKL?induced osteoclastogenesis by inhibiting differentiation and maturation. Nanoscale 34: 12516-12523.
Teitelbaum, S. L. and Ross, F. P. (2003) Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 8: 638-649.
Sakae, T., Ichiro, N., Jun-Ichiro, I., Hiromi, O. and Kozo, N. (2003) Signal transduction pathway regulating osteoclast differentiation and function. J. Bone. Miner. Metab. 21: 123-133.
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