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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,035 - 1,048 (14page)
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초록· 키워드
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Objectives: This study was performed to investigate the effects of Gardenia jasminoides extract (GJ) on osteoclast differentiation and bone resorption in vitro.
Methods: To investigate the effect of GJ on osteoclast differentiation, the mouse leukemic myeloid cell line RAW 264.7 was stimulated by RANKL (receptor activator of nuclear factor kB ligand). Osteoclast differentiation was measured by counting TRAP (+) MNC in the presence of RANKL. To elucidate the mechanism of the inhibitory effect of GJ on osteoclast differentiation, gene expression of TRAP, Cathepsin K, MMP-9, NFATc1, c-Fos, MITF, DC-STAMP, CTR, OC-STAMP and Atp6v0d2 was measured using reverse transcription-PCR (RT-PCR). Bone resorption was measured using the bone pit formation assay.
Results: GJ decreased the number of TRAP (+) MNCs in the presence of RANKL. GJ inhibited the expression of cathepsin K, MMP-9, TRAP, MITF, NFATc1, c-Fos, iNON, OC-STAMP, Atp6v0d2, and DC-STAMP in the osteoclast, and inhibited bone pit formation in vitro.
Conclusions: The results suggest that GJ has inhibitory effects on bone resorption resulting from inhibition of osteoclast differentiation and gene expression.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Akihisa T / 2012 / Melanogenesis inhibitory activity of monoterpene glycosides from Gardeniae Fructus / Chem Biodivers 9 (8) : 1490 ~ 1499
Atkins GJ / 2012 / Osteocyte regulation of bone mineral: a little give and take / Osteoporos Int 23 (8) : 2067 ~ 2079
Chen YH / 2012 / Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile ductligated rats and human hepatic stellate cells / World J Gastroenterol 18 (48)
Drake MT / 2017 / Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned / Endocr Rev 38 (4) : 325 ~ 350
Fong D / 2013 / Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro / Cell Signal 25 (4) : 717 ~ 728
Atkins GJ / 2012 / Osteocyte regulation of bone mineral: a little give and take / Osteoporos Int 23 (8) : 2067 ~ 2079
Chen YH / 2012 / Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile ductligated rats and human hepatic stellate cells / World J Gastroenterol 18 (48)
Drake MT / 2017 / Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned / Endocr Rev 38 (4) : 325 ~ 350
Fong D / 2013 / Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro / Cell Signal 25 (4) : 717 ~ 728
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