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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 135 - 147 (13page)
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Objectives This study was performed to evaluate the effect of Pyrola japonica extract (NJ) and its principal constituent, homoarbutin (HA) on osteoclast differentiation and gene expression and bone resorption. The osteoclastogenesis and gene expression were determined in receptor activator of nuclear factor kappa B ligand (RANKL)-stimulated RAW264.7 cell. Methods In order to evaluate the effect of HA extracted from NJ on bone resorption, osteoclasts were used to be differentiated and formed by stimulating RAW264.7 cells with RANKL. Tartarate-resistant acid phosphatase (TRAP) (+) polynuclear osteoclast formation ability was evaluated, and differentiation control genes including cathepsin K, matrix metalloproteinases-9 (MMP-9), and TRAP in osteoclast differentiation were analyzed by real-time polymerase chain reaction (PCR). Immunoblotting was performed to measure the effect of mitogen-activated protein kinase (MAPK) factors on bone resorption, and the effect of osteoclasts on osteoclast differentiation was measured. Results Both NJ and high concentration of HA blocked RANKL-stimulated differentiation from RAW264.7 cell to TRAP-positive multinucleated cells. NJ reduced RANKL-induced expression of TRAP, cathepsin K. Both NJ and high concentration of HA inhibited RANKL-mediated expression of MMP-9, nuclear factor of activated T-cells, cytoplasmic 1, and cellular Jun-fos. NJ suppressed RANKL-stimulated expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase, tumor necrosis factor-alpha, and levels of interleukins. Both NJ and HA decreased bone resorption in osteoclast-induced bone pit formation model. Conclusions These results suggest that NJ and HA blocked bone resorption by decreasing RANKL-mediated osteoclastogenesis through down-regulation of genes for osteoclast differentiation.
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참고문헌 (27)
참고문헌 신청
Thompson WR / 2012 / Mechanical regulation of signaling pathways in bone / Gene 503(2):179~193
The Society of Korean Medicine Rehabilitation / 2015 / Korean Medicine Rehabilitation / Koonja Publishing :133
Michou L / 2011 / Genetics of bone diseases : Paget's disease, fibrous dysplasia, osteopetrosis, and osteogenesis imperfecta / Joint Bone Spine 78(3):252~258
Hiasa M / 2009 / GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme(TACE) / Blood 114(20):4517~4526
Fujisaki K / 2007 / Receptor activator of NF-kappa B ligand induces the expression of carbonic anhydrase II, cathepsin K, and matrix metalloproteinase- 9 in osteoclast precursor RAW264.7 cells / Life Sciences 80(14):1311~1318
The Society of Korean Medicine Rehabilitation / 2015 / Korean Medicine Rehabilitation / Koonja Publishing :133
Michou L / 2011 / Genetics of bone diseases : Paget's disease, fibrous dysplasia, osteopetrosis, and osteogenesis imperfecta / Joint Bone Spine 78(3):252~258
Hiasa M / 2009 / GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme(TACE) / Blood 114(20):4517~4526
Fujisaki K / 2007 / Receptor activator of NF-kappa B ligand induces the expression of carbonic anhydrase II, cathepsin K, and matrix metalloproteinase- 9 in osteoclast precursor RAW264.7 cells / Life Sciences 80(14):1311~1318
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