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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 144 - 158 (15page)
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Cancer immunotherapies continue to face numerous obstacles in the successful treatment of solid malignancies. While immunotherapy has emerged as an extremely effective treatment option for hematologic malignancies, it is largely ineffective against solid tumors due in part to metabolic challenges present in the tumor microenvironment (TME). Tumorinfiltrating CD8<SUP>+</SUP> T cells face fierce competition with cancer cells for limited nutrients. The strong metabolic suppression in the TME often leads to impaired T-cell recruitment to the tumor site and hyporesponsive effector functions via T-cell exhaustion. Growing evidence suggests that mitochondria play a key role in CD8<SUP>+</SUP> T-cell activation, migration, effector functions, and persistence in tumors. Therefore, targeting the mitochondrial metabolism of adoptively transferred T cells has the potential to greatly improve the effectiveness of cancer immunotherapies in treating solid malignancies.
목차
ABSTRACT
INTRODUCTION
METABOLIC DYNAMICS OF CD8+ T CELLS
CHALLENGES OF T-CELL IMMUNOTHERAPIES
TARGETING T-CELL MITOCHONDRIAL METABOLISM TO IMPROVE CANCER IMMUNOTHERAPY
CONCLUDING REMARKS
REFERENCES
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