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논문 기본 정보

자료유형
학술저널
저자정보
Jung Ah Kim (Yonsei University College of Medicine) Sung-Hee Kim (Yonsei University College of Medicine) Jung Seon Seo (Yonsei University College of Medicine) 노현아 (재단법인 국가마우스표현형분석사업단) Haengdueng Jeong (Yonsei University College of Medicine) Jiseon Kim (Yonsei University College of Medicine) Donghun Jeon (Yonsei University College of Medicine) Jeong Jin Kim (Yonsei University College of Medicine) Dain On (서울대학교) 윤서연 (재단법인 국가마우스표현형분석사업단) Sang Gyu Lee (Interdisciplinary Program for Bioinformatics Seoul National University) 이윤우 (서울대학교) Hui Jeong Jang (Seoul National University Bundang Hospital) In Ho Park (Yonsei University College of Medicine) Jooyeon Oh (Yonsei University College of Medicine) Sang-Hyuk Seok (Kangwon National University) Yu Jin Lee (Kangwon National University) 홍승민 (서울대학교) 안세희 (서울대학교) Joon-Yong Bae (College of Medicine Korea University) 최정아 (국제백신연구소(IVI)) Seo Yeon Kim (Seoul National University Bundang Hospital) Young Been Kim (Seoul National University Bundang Hospital) 황지연 (분당서울대학교병원) 이효정 (분당서울대학교병원) Hong Bin Kim (Seoul National University Bundang Hospital) 정대균 (한국생명공학연구원) Daesub Song (Seoul National University) 송만기 (국제백신연구소(IVI)) 박만성 (고려대학교) Kang-Seuk Choi (Seoul National University) 박준원 (강원대학교) Jun-Won Yun (Seoul National University) 신전수 (연세대학교) Ho-Young Lee (Seoul National University Bundang Hospital) 서준영 (연세대학교) Ki Taek Nam (Yonsei University College of Medicine) Heon Yung Gee (Yonsei University College of Medicine) Je Kyung Seong (Seoul National University)
저널정보
한국분자세포생물학회 Molecules and Cells Molecules and Cells 제45권 제12호
발행연도
2022.12
수록면
896 - 910 (15page)
DOI
10.14348/molcells.2022.0089

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초록· 키워드

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and potentially fatal virus. So far, most comprehensive analyses encompassing clinical and transcriptional manifestation have concentrated on the lungs. Here, we confirmed evident signs of viral infection in the lungs and spleen of SARS-CoV-2-infected K18-hACE2 mice, which replicate the phenotype and infection symptoms in hospitalized humans. Seven days post viral detection in organs, infected mice showed decreased vital signs, leading to death. Bronchopneumonia due to infiltration of leukocytes in the lungs and reduction in the spleen lymphocyte region were observed. Transcriptome profiling implicated the meticulous regulation of distress and recovery from cytokine-mediated immunity by distinct immune cell types in a time-dependent manner. In lungs, the chemokine-driven response to viral invasion was highly elevated at 2 days post infection (dpi). In late infection, diseased lungs, post the innate immune process, showed recovery signs. The spleen established an even more immediate line of defense than the lungs, and the cytokine expression profile dropped at 7 dpi. At 5 dpi, spleen samples diverged into two distinct groups with different transcriptome profile and pathophysiology. Inhibition of consecutive host cell viral entry and massive immunoglobulin production and proteolysis inhibition seemed that one group endeavored to survive, while the other group struggled with developmental regeneration against consistent viral intrusion through the replication cycle. Our results may contribute to improved understanding of the longitudinal response to viral infection and development of potential therapeutics for hospitalized patients affected by SARS-CoV-2.

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