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논문 기본 정보

자료유형
학술저널
저자정보
Noh Hye-Ji (Probiotics Research Laboratory Chong Kun Dang Bio Research Institute (CKDBIO) Gyeonggi 15064 Republ) Park Jung Min (R&D Center Chong Kun Dang Healthcare (CKDHC) Seoul 07249 Republic of Korea) Kwon Yoo Jin (Probiotics Research Laboratory Chong Kun Dang Bio Research Institute (CKDBIO) Gyeonggi 15064 Republ) Kim Kyunghwan (Probiotics Research Laboratory Chong Kun Dang Bio Research Institute (CKDBIO) Gyeonggi 15064 Republ) Park Sung Yurb (Probiotics Research Laboratory Chong Kun Dang Bio Research Institute (CKDBIO) Gyeonggi 15064 Republ) Kim Insu (R&D Center Chong Kun Dang Healthcare (CKDHC) Seoul 07249 Republic of Korea) Lim Jong Hyun (R&D Center Chong Kun Dang Healthcare (CKDHC) Seoul 07249 Republic of Korea) Kim Byoung Kook (Probiotics Research Laboratory Chong Kun Dang Bio Research Institute (CKDBIO) Gyeonggi 15064 Republ) 김병용 (R&D Center Chong Kun Dang Healthcare (CKDHC) Seoul 07249 Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제32권 제5호
발행연도
2022.5
수록면
638 - 644 (7page)
DOI
10.4014/jmb.2201.01015

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Probiotics modulate the gut microbiota, which in turn regulate immune responses to maintain balanced immune homeostasis in the host. However, it is unclear how probiotic bacteria regulate immune responses. In this study we investigated the immunomodulatory effects of heat-killed probiotics, including Lactiplantibacillus plantarum KC3 (LP3), Lactiplantibacillus plantarum CKDB008 (LP8), and Limosilactobacillus fermentum SRK414 (LF4), via phagocytosis, nitric oxide (NO), and pro-inflammatory cytokine production in macrophages. We thus found that heat-killed LP8 could promote the clearance of foreign pathogens by enhancing the phagocytosis of macrophages. Treatment with heat-killed LP8 induced the production of NO and pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β. In addition, heat-killed LP8 suppressed the production of NO and cytokines in LPS-induced RAW264.7 cells, suggesting that heat-killed LP8 exerts immunomodulatory effects depending on the host condition. In sum, these results indicate that heat-killed LP8 possesses the potential for immune modulation while providing a molecular basis for the development of functional probiotics prepared from inactivated bacterial cells.

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