지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제26권 제6호
- 발행연도
- 2022.11
- 수록면
- 531 - 540 (10page)
- DOI
- 10.4196/kjpp.2022.26.6.531
이용수
이 논문의 연구 히스토리 (3)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Group 1 metabotropic glutamate receptors (mGluRs) can positively affect postsynaptic neuronal excitability and epileptogenesis. The objective of the present study was to determine whether group 1 mGluRs might be involved in synapticallyinduced intracellular free Ca2+ concentration ([Ca2+]i) spikes and neuronal cell death induced by 0.1 mM Mg2+ and 10 µM glycine in cultured rat hippocampal neurons from embryonic day 17 fetal Sprague–Dawley rats using imaging methods for Ca2+ and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays for cell survival. Reduction of extracellular Mg2+ concentration ([Mg2+]o) to 0.1 mM induced repetitive [Ca2+]i spikes within 30 sec at day 11.5. The mGluR5 antagonist 6-Methyl- 2-(phenylethynyl) pyridine (MPEP) almost completely inhibited the [Ca2+]i spikes, but the mGluR1 antagonist LY367385 did not. The group 1 mGluRs agonist, 3,5-dihydroxyphenylglycine (DHPG), significantly increased the [Ca2+]i spikes. The phospholipase C inhibitor U73122 significantly inhibited the [Ca2+]i spikes in the absence or presence of DHPG. The IP3 receptor antagonist 2-aminoethoxydiphenyl borate or the ryanodine receptor antagonist 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate also significantly inhibited the [Ca2+]i spikes in the absence or presence of DHPG.
The TRPC channel inhibitors SKF96365 and flufenamic acid significantly inhibited the [Ca2+]i spikes in the absence or presence of DHPG. The mGluR5 antagonist MPEP significantly increased the neuronal cell survival, but mGluR1 antagonist LY367385 did not. These results suggest a possibility that mGluR5 is involved in synapticallyinduced [Ca2+]i spikes and neuronal cell death in cultured rat hippocampal neurons by releasing Ca2+ from IP3 and ryanodine-sensitive intracellular stores and activating TRPC channels.
INTRODUCTION Glutamate can activate non-N-methyl-D-aspartate (non- NMDA) receptors, leading to depolarize membranes in neurons.
This depolarization can induce Ca2+ influx from the extracellular space by decreasing Mg2+ block of N-methyl-D-aspartate (NMDA) receptors and activating voltage-gated Ca2+ channels. Glutamate can also induce the release of Ca2+ from intracellular stores throu
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Chronic Ca2+ influx through voltage-dependent Ca2+ channels enhance delayed rectifier K+ currents via activating Src family tyrosine kinase in rat hippocampal neurons
The Korean Journal of Physiology & Pharmacology
2017 .03
-
미토콘드리아 기능을 통해 내인성 글루탐산이 신경세포 생존에 미치는 영향
의생명과학
2018 .01
-
Hydrogen peroxide attenuates refilling of intracellular calcium store in mouse pancreatic acinar cells
The Korean Journal of Physiology & Pharmacology
2017 .03
-
Effect of arsenic exposure on the expression of metabotropic glutamate receptors in brain of C57BL/6 mice
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Postsynaptic N-type or P/Q-type voltage-gated calcium channels mediate the induction of long-term potentiation by group I metabotropic glutamate receptors at trigeminal excitatory synapses in the rat spinal trigeminal oralis
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Ryanodine Receptor-mediated Calcium Release Regulates Neuronal Excitability in Rat Spinal Substantia Gelatinosa Neurons
International Journal of Oral Biology
2015 .01
-
Hydrogen peroxide inhibits Ca2+ efflux through plasma membrane Ca2+-ATPase in mouse parotid acinar cells
The Korean Journal of Physiology & Pharmacology
2018 .03
-
Action of Mitochondrial Substrates on Neuronal Excitability in Rat Substantia Gelatinosa Neurons
International Journal of Oral Biology
2017 .01
-
Childhood Onset of Anti-N-Methyl-D-Aspartate Receptor Encephalitis Without Teratoma Masquerading as a Psychotic Disorder
소아청소년정신의학
2019 .07
-
Protective effect of the aerial parts of Silybum marianum against amyloid β protein (25-35)-induced neuronal death in cultured neurons
Journal of Biomedical and Translational Research
2016 .12
-
Resveratrol reduces the glutamate-induced cell death in hippocampal neurons
한국실험동물학회 학술발표대회 논문집
2015 .08
-
[해부생리] Metabotropic glutamate receptor 5 enhances cytotoxic effect of NK cells against hepatic stellate cells and ameliorates liver fibrosis
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Neuronal death in the CNS autonomic control center comes very early after cardiac arrest and is not significantly attenuated by prompt hypothermic treatment in rats
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Cyanidin-3-glucoside inhibits amyloid β25-35-induced neuronal cell death in cultured rat hippocampal neurons
The Korean Journal of Physiology & Pharmacology
2018 .11
-
우울증 치료에서 빠른 효과와 적은 부작용을 가진 새로운 N-Methyl-D-Aspartate(NMDA) 수용체 길항제
생물정신의학
2015 .01
-
Alpha1-Adrenoceptor Antagonists Improve Memory by Activating N-Methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus
International Neurourology Journal
2015 .01
-
Resveratrol attenuates N-methyl-D-aspartate receptor-mediated activation in substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice
Oral Biology Research
2023 .06
-
Korean red ginseng excitation of paraventricular nucleus neurons via non-N-methyl-D-aspartate glutamate receptor activation in mice
Journal of Veterinary Science
2018 .03
-
NMDA receptor dysfunction in mouse models of autism
대한소아청소년정신의학회 학술대회논문집
2018 .11
-
Applicative Value of Serum CA19-9, CEA, CA125 and CA242 in Diagnosis and Prognosis for Patients with Pancreatic Cancer Treated by Concurrent Chemoradiotherapy
Asian Pacific journal of cancer prevention : APJCP
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0