지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 228 - 236 (9page)
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초록· 키워드
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Purpose: Alpha1 (α1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the central nervous system. Therefore, α1- adrenoceptor antagonists may enhance brain functions. In the present study, we investigated the effects of tamsulosin, an α1- adrenoceptor antagonist, on short-term memory, as well as spatial learning and memory, in rats.
Methods: The step-down avoidance test was used to evaluate short-term memory, and an eight-arm radial maze test was used to evaluate spatial learning and memory. TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling) staining was performed in order to evaluate the effect of tamsulosin on apoptosis in the hippocampal dentate gyrus. Patch clamp recordings were used to evaluate the effect of tamsulosin on ionotropic glutamate receptors, such as N-methyl-D-aspartate (NMDA), amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate receptors, in hippocampal CA1 neurons.
Results: Tamsulosin treatment improved short-term memory, as well as spatial learning and memory, without altering apoptosis.
The amplitudes of NMDA-induced ion currents were dose-dependently increased by tamsulosin. However, the amplitudes of AMPA- and kainate-induced ion currents were not affected by tamsulosin.
Conclusions: Tamsulosin enhanced memory function by activating NMDA receptor-mediated ion currents in the hippocampus without initiating apoptosis. The present study suggests the possibility of using tamsulosin to enhance memory under normal conditions, in addition to its use in treating overactive bladder.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Abrams P / 2003 / Describing bladder storage function: overactive bladder syndrome and detrusor overactivity / Urology 62 (5 Suppl 2) : 28 ~ 37
Andersson KE / 2009 / Pharmacotherapy of the overactive bladder / Discov Med 8 : 118 ~ 124
Athanasopoulos A / 2003 / Combination treatment with an alpha-blocker plus an anticholinergic for bladder outlet obstruction: a prospective, randomized, controlled study / J
Barendrecht MM / 2008 / Do alpha1-adrenoceptor antagonists improve lower urinary tract symptoms by reducing bladder outlet resistance / Neurourol Urodyn 27 : 226 ~ 230
Chu FM / 2006 / Pathophysiology of overactive bladder / Am J Med 119 (3 Suppl 1) : 3 ~ 8
Andersson KE / 2009 / Pharmacotherapy of the overactive bladder / Discov Med 8 : 118 ~ 124
Athanasopoulos A / 2003 / Combination treatment with an alpha-blocker plus an anticholinergic for bladder outlet obstruction: a prospective, randomized, controlled study / J
Barendrecht MM / 2008 / Do alpha1-adrenoceptor antagonists improve lower urinary tract symptoms by reducing bladder outlet resistance / Neurourol Urodyn 27 : 226 ~ 230
Chu FM / 2006 / Pathophysiology of overactive bladder / Am J Med 119 (3 Suppl 1) : 3 ~ 8
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