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논문 기본 정보

자료유형
학술저널
저자정보
Gilles Houvenaeghel (Institut Paoli Calmettes Oncology Surgery 2 232 Boulevard Sainte Marguerite Marseille France) Alexandre de Nonneville (Institut Paoli Calmettes Department of Medical Oncology Marseille France) Guillaume Blache (Institut Paoli Calmettes Department of Surgical Oncology Marseille France) Max Buttarelli (Institut Paoli Calmettes Department of Surgical Oncology Marseille France) Camille Jauffret (Institut Paoli Calmettes Department of Surgical Oncology Marseille France) Djamel Mokart (Institut Paoli Calmettes Department of Anesthesiology and Critical Care Marseille France) Laura Sabiani (Institut Paoli Calmettes Department of Surgical Oncology Marseille France)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.33 No.3
발행연도
2022.5
수록면
1 - 14 (14page)
DOI
https://doi.org/10.3802/jgo.2022.33.e31

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Objective: Posterior pelvic exenteration (PPE) can be required to achieve complete resection in ovarian cancer (OC) patients with large pelvic disease. This study aimed to analyze morbidity, complete resection rate, and survival of PPE. Methods: Ninety patients who underwent PPE in our Comprehensive Cancer Center between January 2010 and February 2021 were retrospectively identified. To analyze practice evolution, 2 periods were determined: P1 from 2010 to 2017 and P2 from 2018 to 2021. Results: A 82.2% complete resection rate after PPE was obtained, with rectal anastomosis in 96.7% of patients. Complication rate was at 30% (grade 3 in 9 patients), without significant difference according to periods or quality of resection. In a binary logistic regression adjusted on age and stoma, only age of 51?74 years old was associated with a lower rate of complication (odds ratio=0.223; p=0.026). Median overall and disease-free survivals (OS and DFS) from initial diagnosis were 75.21 and 29.84 months, respectively. A negative impact on OS and DFS was observed in case of incomplete resection, and on DFS in case of final cytoreductive surgery (FCS: after ≥6 chemotherapy cycles). Age ≥75-years had a negative impact on DFS for new OC surgery. For patients with complete resection, OS and DFS were decreased in case of interval cytoreductive surgery and FCS in comparison with primary cytoreductive surgery. Conclusion: PPE is an effective surgical measure to achieve complete resection for a majority of patients. High rate of colorectal anastomosis was achieved without any mortality, with acceptable morbidity and high protective stoma rate.

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