지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 1 - 13 (13page)
- DOI
- https://doi.org/10.3802/jgo.2022.33.e59
이용수
초록· 키워드
오류제보하기
Objective: Regional control is occasionally unsatisfactory in cervical cancer, with the optimal radiation dose for nodal metastases in definitive radiotherapy (RT) with concurrent chemotherapy (CRT) remaining controversial. We investigated dose-response relationship for nodal local control in cervical cancer.
Methods: We identified 115 patients with 417 metastatic nodes who received definitive CRT for cervical cancer with nodal metastases. External beam radiation therapy and brachytherapy plans were summated to determine total dose received by each node. Prognostic factors of nodal control and dose-response relationship were investigated using Cox-regression and restricted cubic spline function.
Results: The 2-year progression-free survival rate was 69.4%. Among 43 patients with failures, 17 patients (37.5%) had regional failure included in first failure sites of which all except one were in-field only regional failures. Total 30 nodes showed recurrence at initial metastatic site after treatment. Neutrophil-to-lymphocyte ratio (NLR) ≥3.1, total radiation dose (minimum dose received by 98% of the target volume in equivalent dose in 2 Gy per fractions), and initial nodal volume ≥5.29 mL were poor prognostic factors (all p<0.050) of nodal local control. Restricted cubic spline functions revealed strongest dose-response relationship in high NLR (NLR ≥3.1) and initial nodal volume ≥5.29 mL subgroup. Conclusion: Initial nodal volume, radiation dose, and NLR were significant factors of nodal local control in cervical cancer; a stronger dose-response relationship was seen in bulky nodes with high NLR. Clinicians may consider these factors when determining the RT dose and the need for boost to nodal metastases in cervical cancer.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Lymph node size and its association with nodal metastasis in ductal adenocarcinoma of the pancreas
Journal of Pathology and Translational Medicine
2020 .01
-
In which group of gastric cancer patients is the preoperative neutrophil-to-lymphocyte ratio a significant prognostic factor?
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2016 .06
-
Preoperative neutrophil-to-lymphocyte ratio is a prognostic factor for overall survival in patients with gastric cancer
Annals of Surgical Treatment and Research
2015 .07
-
The Lymph Nodal Stations which Have an Influence on Splenic Hilar Nodal Metastasis among the Upper Advanced Gastric Cancer Not Invading the Greater Curvature
대한외과학회 학술대회 초록집
2022 .11
-
Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers
International Journal of Thyroidology
2018 .01
-
Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio
Clinical and Molecular Hepatology
2019 .01
-
경부 림프절 전이를 동반한 갑상선유두암 환자에서 혈중 호중구 림프구 비율의 임상적 의의
International Journal of Thyroidology
2017 .01
-
Preoperative Neutrophil to Lymphocyte Ratio as a Prognostic Factor in Patients with Non-metastatic Renal Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The Neutrophil to Lymphocyte Ratio is an Independent Prognostic Factor in Patients with Metastatic Gastric Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Long Term Outcome in Patients with Nodal-positive Breast Cancer Treated with Sentinel Lymph Node Biopsy Alone after Neoadjuvant Chemotherapy
대한외과학회 학술대회 초록집
2022 .11
-
Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
Annals of Surgical Treatment and Research
2019 .04
-
Could the Breast Prognostic Biomarker Status Change During Disease Progression? An Immunohistochemical Comparison between Primary Tumors and Synchronous Nodal Metastasis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Dose-Response Relationship between Radiation Dose and Loco-regional Control in Patients with Stage II-III Esophageal Cancer Treated with Definitive Chemoradiotherapy
Cancer Research and Treatment
2017 .07
-
Significance of histology and nodal status on the survival of women with early-stage cervical cancer: validation of the 2018 FIGO cervical cancer staging system
Journal of Gynecologic Oncology
2022 .05
-
Sentinel node mapping in endometrial cancer
Journal of Gynecologic Oncology
2024 .01
-
Comparison of Predictive Performance among Current Nodal Staging Systems for Prognosis of Pancreatic Cancer
대한외과학회 학술대회 초록집
2020 .11
-
Five-year Survival Associated with Stage I Gastric Cancer after Resection of Early Recurrence at Nodal Station No. 14v: a Case Report
Journal of Gastric Cancer
2017 .06
-
Pretreatment neutrophil-to-lymphocyte ratio and its dynamic change during neoadjuvant chemotherapy as poor prognostic factors in advanced ovarian cancer
Obstetrics & Gynecology Science
2018 .01
-
Postmastectomy Radiation and Regional Nodal Irradiation after Breast Cancer Surgery
대한외과학회 학술대회 초록집
2020 .11
-
Neutrophil to Lymphocyte Ratio after Treatment Completion as a Potential Predictor of Survival in Patients with Triple-Negative Breast Cancer
Journal of Breast Cancer
2021 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0