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논문 기본 정보

자료유형
학술저널
저자정보
Nam Seung-Joo (Department of Internal Medicine Kangwon National University School of Medicine Chuncheon Korea) Kim Byung Chang (Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang Korea) Chang Hee Jin (Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang KoreaDep) Jeon Han Ho (Department of Internal Medicine National Health Insurance Service Ilsan Hospital Goyang Korea) Kim Junho (Department of Internal Medicine National Health Insurance Service Ilsan Hospital Goyang Korea) Kim Su Young (Divison of Gastroenterology Department of Internal Medicine Yonsei University Wonju College of Medi)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제16권 제2호
발행연도
2022.3
수록면
228 - 235 (8page)
DOI
10.5009/gnl20364

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Background/Aims: Small rectal neuroendocrine tumors (NETs) are often managed with local resection (endoscopic or transanal excision) owing to their low risk of metastasis and recurrence. However, the clinical significance of lymphovascular invasion in resected specimens remains controversial. In this study, we aimed to analyze the frequency of and risk factors for lymph node metastasis proven by histopathologic examination after radical resection. Methods: We retrospectively reviewed the records of 750 patients diagnosed with a rectal NET at four academic medical centers in South Korea between 2001 and 2019. The frequency of histopathologically proven lymph node metastasis and the associated risk factors were analyzed for small tumors (≤1.5 cm) with lymphovascular invasion. Results: Among 750 patients, 75 had a small tumor (≤1.5 cm) with lymphovascular invasion, of whom 31 patients underwent endoscopic resection only and 44 patients underwent additional radical surgery. Among the 41 patients who underwent surgery and had available data, the rate of regional lymph node metastasis was 48.8% (20/41). In multivariate analysis, the Ki-67 index (odds ratio, 6.279; 95% confidence interval, 1.212 to 32.528; p=0.029) was an independent risk factor for lymph node metastasis. During the mean follow-up period of 37.7 months, only one case of recurrence was detected in the surgery group. The overall survival was not significantly different between radical resection and local resection (p=0.332). Conclusions: Rectal NETs with lymphovascular invasion showed a significantly high rate of regional lymph node metastasis despite their small size (≤1.5 cm).

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