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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.1
- 수록면
- 33 - 39 (7page)
- DOI
- 10.47429/lmo.2022.12.1.33
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초록· 키워드
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Background: Complete blood cell count (CBC) test, peripheral blood smears (PBS), and automatic hematology analyzers are used to screen pa- tients with high-risk hematology malignancies. In this study, the workflow of urgent and routine samples and methods to improve the detection rate of blasts were evaluated. The purpose of this study was to validate the hematology rapid reporting system (HRS) for CBC and establish a strategy for the effective use of an automated hematology analyzer in clinical laboratories.
Methods: The flag performances of UniCel DxH 800 (Beckman Coulter, USA) and XE-2100 (Sysmex, Japan) systems used for blood tests were analyzed for urgent and routine samples. The results were compared with PBS results. Each test method’s sensitivity and specificity were deter- mined to identify the most efficient blast detection method. In addition, receiver operating characteristic (ROC) curves of various parameters such as CBC and age were analyzed.
Results: The sensitivity and specificity of HRS were 66.80% and 99.85%, respectively, with urgent flags (four flags) and 92.95% and 98.49%, respectively, with routine flags (15 flags). The sensitivity of HRS for routine samples was significantly different from that for urgent samples (66.80% vs. 92.95%; < 0.0001), but no significant difference was observed in the specificity for HRS between routine and urgent samples (99.85% vs. 98.49%; = 1.00).
Conclusions: HRS using flags and blast history can be effectively used in clinical laboratories. HRS can be used as an effective reporting work- flow for differential CBC in clinical laboratories.
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