지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 1 - 11 (11page)
- DOI
- 10.1038/s12276-021-00657-0
이용수
초록· 키워드
오류제보하기
Compelling evidence has indicated the vital role of lysine-specific demethylase 4?A (KDM4A), hypoxia-inducible factor-1α (HIF1α) and the mechanistic target of rapamycin (mTOR) signaling pathway in nasopharyngeal carcinoma (NPC). Therefore, we aimed to investigate whether KDM4A affects NPC progression by regulating the HIF1α/DDIT4/mTOR signaling pathway. First, NPC and adjacent tissue samples were collected, and KDM4A protein expression was examined by immunohistochemistry. Then, the interactions among KDM4A, HIF1α and DDIT4 were assessed. Gain- and loss-of-function approaches were used to alter KDM4A, HIF1α and DDIT4 expression in NPC cells. The mechanism of KDM4A in NPC was evaluated both in vivo and in vitro via RT-qPCR, Western blot analysis, MTT assay, Transwell assay, flow cytometry and tumor formation experiments. KDM4A, HIF1α, and DDIT4 were highly expressed in NPC tissues and cells. Mechanistically, KDM4A inhibited the enrichment of histone H3 lysine 9 trimethylation (H3K9me3) in the HIF1α promoter region and thus inhibited the methylation of HIF1α to promote HIF1α expression, thus upregulating DDIT4 and activating the mTOR signaling pathway. Overexpression of KDM4A, HIF1α, or DDIT4 or activation of the mTOR signaling pathway promoted SUNE1 cell proliferation, migration, and invasion but inhibited apoptosis. KDM4A silencing blocked the mTOR signaling pathway by inhibiting the HIF1α/DDIT4 axis to inhibit the growth of SUNE1 cells in vivo. Collectively, KDM4A silencing could inhibit NPC progression by blocking the activation of the HIF1α/DDIT4/mTOR signaling pathway by increasing H3K9me3, highlighting a promising therapeutic target for NPC.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis
Experimental and Molecular Medicine
2022 .12
-
Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B
BMB Reports
2015 .01
-
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism
Experimental and Molecular Medicine
2019 .01
-
SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation
Experimental and Molecular Medicine
2021 .02
-
Hypoxia signaling in human diseases and therapeutic targets
Experimental and Molecular Medicine
2019 .01
-
Regulation of HIF-1α stability by lysine methylation
BMB Reports
2016 .01
-
Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity
Experimental and Molecular Medicine
2015 .01
-
Determination of HIF-1α degradation pathways via modulation of the propionyl mark
BMB Reports
2023 .04
-
사물인터넷을 이용한 디지털 도어락, DDiT의 설계 및 구현
정보과학회 컴퓨팅의 실제 논문지
2015 .03
-
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Experimental and Molecular Medicine
2024 .03
-
Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss
Experimental and Molecular Medicine
2021 .04
-
Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
BMB Reports
2016 .01
-
Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway
조직공학과 재생의학
2021 .12
-
Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9
Experimental and Molecular Medicine
2022 .07
-
Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ
Experimental and Molecular Medicine
2024 .07
-
건강보험 빅데이터를 활용한 생물학적 나이 추정 모형 비교 연구
보건정보통계학회지
2024 .08
-
Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition
Experimental and Molecular Medicine
2019 .01
-
Cadmium-induced ER stress and inflammation are mediated through C/EBP–DDIT3 signaling in human bronchial epithelial cells
Experimental and Molecular Medicine
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0