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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 458 - 465 (8page)
- DOI
- 10.48022/mbl.2104.04014
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초록· 키워드
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Tubulysins are a group of bioactive secondary metabolites from myxobacteria exhibiting strong anticancer activity against various cancer cell lines. In this study, we describe the identification of putative tubulysin biosynthetic gene clusters (tubA~tubF) in the genome sequences of two tubulysin-producing myxobacterial strains, Archangium gephyra MEHO_002 and MEHO_004. The inactivation of the putative tubulysin biosynthetic genes resulted in a tubulysin-production defect. The DNA sequences of the A. gephyra MEHO_002 and MEHO_004 tubulysin biosynthetic genes were 97% identical, and the amino acid sequences of the encoded proteins shared a similarity of 97?100%. The nucleotide sequences of the tubulysin biosynthetic gene clusters in MEHO_002 and MEHO_004 were 86% identical to that in Cystobacter sp. SBCb004 known as a tubulysin-producing myxobacterium, and the organization of the clusters was identical except for the lack of a tubZ gene in the clusters in MEHO_002 and MEHO_004. The amino acid sequences of the proteins encoded by each gene were 88-97% similar to those encoded by SBCb004, and the domain compositions of the proteins were also identical.
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참고문헌 (25)
참고문헌 신청
Etienne-Manneville S / 2010 / From signaling pathways to microtubule dynamics : the key players / Curr. Opin. Cell Biol 22:104~111
Risinger AL / 2009 / Microtubule dynamics as a target in oncology / Cancer Treat. Rev 35:255~261
Sasse F / 2000 / Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties / J. Antibiot 53:879~885
Khalil MW / 2006 / Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria / ChemBioChem 7:678~683
Chai Y / 2010 / Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004 / Chem. Biol 17:296~309
Risinger AL / 2009 / Microtubule dynamics as a target in oncology / Cancer Treat. Rev 35:255~261
Sasse F / 2000 / Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties / J. Antibiot 53:879~885
Khalil MW / 2006 / Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria / ChemBioChem 7:678~683
Chai Y / 2010 / Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004 / Chem. Biol 17:296~309
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