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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 493 - 500 (8page)
- DOI
- 10.48022/mbl.2107.07009
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초록· 키워드
오류제보하기
Argyrins are a group of anticancer and antibacterial octapeptide bioactive substances isolated from myxobacteria.
In this study, we showed that the myxobacterium Archangium gephyra MEHO_001, isolated in Korea, produces argyrins A and B. MEHO_001 cells tend to aggregate when cultured in liquid media.
Hence, a dispersion mutant, MEHO_002, was isolated from MEHO_001. The MEHO_002 strain produced approximately 3.5 times more argyrins than that produced by the wild-type strain MEHO_001. We determined the whole-genome sequence of A. gephyra MEHO_002 and identified a putative argyrin biosynthetic gene cluster comprising five genes, arg1-arg5, encoding non-ribosomal peptide synthases and tailoring enzymes.
Inactivation of arg2 by plasmid insertion disrupted argyrin production. The amino acid sequences of the proteins encoded by arg2-arg5 of A. gephyra MEHO_002 were 90-98% similar to those encoded by the argyrin biosynthetic genes of Cystobacter sp. SBCb004, an argyrin-producing myxobacterium with identical domain organization.
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참고문헌 (25)
참고문헌 신청
Sasse F / 2002 / Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties / J. Antibiot 55:543~551
Vollbrecht L / 2002 / Argyrins, immunosuppressive cyclic peptides from myxobacteria. II. Structure elucidation and stereochemistry / J. Antibiot 55:715~721
Ferrari P / 1996 / Antibiotics A21459 A and B, new inhibitors of bacterial protein synthesis. II. Structure elucidation / J. Antibiot 49:150~154
Selva E / 1996 / Antibiotics A21459 A and B, new inhibitors of bacterial protein synthesis. I. Taxonomy, isolation and characterization / J. Antibiot 49:145~149
Pogorevc D / 2019 / Biosynthesis and heterologous production of argyrins / ACS Synth. Biol 8:1121~1133
Vollbrecht L / 2002 / Argyrins, immunosuppressive cyclic peptides from myxobacteria. II. Structure elucidation and stereochemistry / J. Antibiot 55:715~721
Ferrari P / 1996 / Antibiotics A21459 A and B, new inhibitors of bacterial protein synthesis. II. Structure elucidation / J. Antibiot 49:150~154
Selva E / 1996 / Antibiotics A21459 A and B, new inhibitors of bacterial protein synthesis. I. Taxonomy, isolation and characterization / J. Antibiot 49:145~149
Pogorevc D / 2019 / Biosynthesis and heterologous production of argyrins / ACS Synth. Biol 8:1121~1133
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